Çalım Gürbüz Begüm, Söylemez Akkurt Tuçe, Eren Handan, İzol Özmen Hazal, Şen Ebru, Pehlivanoğlu Burçin
Başakşehir Çam and Sakura City Hospital, Clinic of Medical Pathology, İstanbul, Türkiye.
Başakşehir Çam and Sakura City Hospital, Clinic of General Surgery, İstanbul, Türkiye.
Medeni Med J. 2024 Dec 27;39(4):302-308. doi: 10.4274/MMJ.galenos.2024.66169.
Angiotropism/perivascular invasion (PVI) is an emerging topic in various types of cancer, with studies primarily focusing on melanoma. However, limited data are available on the significance of PVI in breast cancer. This study aimed to assess the prognostic significance of PVI in breast cancer and its correlation with traditional clinicopathological prognostic parameters.
A total of 150 patients with breast cancer diagnosed between July 2020 and January 2022 were included. Clinicopathological data were retrieved from the hospital records. The presence of PVI was evaluated on hematoxylin&eosin stained slides, and the association between PVI and clinicopathological parameters was statistically analyzed. A p-value of <0.05 was regarded as statistically significant.
All patients were female. The mean age was 54.0±13.6 years (range 26-97 years). PVI was significantly more common in patients with ≥2.5 cm tumors and the absence of PVI showed a significant correlation with a lower histologic grade (p=0.004 and p=0.040, respectively). Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). There was a statistically significant association between the absence of both PVI and extranodal extension (ENE) (p=0.035).
The specific role of PVI in different types of cancer has not yet been clarified. Our findings showed that PVI was significantly associated with tumor size, histological grade, LVI, PNI, and ENE, all of which are well-known negative prognostic factors in breast cancer. The presence of PVI is a promising topic in breast cancer research, and the PVI status in pathology reports may help oncologists perform better risk assessments for patients with breast carcinoma.
血管侵袭/血管周围侵犯（PVI）是各类癌症中一个新兴的研究课题，相关研究主要集中在黑色素瘤。然而，关于PVI在乳腺癌中的意义的数据有限。本研究旨在评估PVI在乳腺癌中的预后意义及其与传统临床病理预后参数的相关性。
纳入2020年7月至2022年1月期间诊断的150例乳腺癌患者。从医院记录中获取临床病理数据。在苏木精-伊红染色切片上评估PVI的存在情况，并对PVI与临床病理参数之间的关联进行统计学分析。p值<0.05被视为具有统计学意义。
所有患者均为女性。平均年龄为54.0±13.6岁（范围26 - 97岁）。PVI在肿瘤≥2.5 cm的患者中明显更常见，且无PVI与较低的组织学分级显著相关（分别为p = 0.004和p = 0.040）。血管淋巴管侵犯（LVI）和神经周围侵犯（PNI）在有PVI的肿瘤中也明显更频繁（分别为p = 0.001和0.02）。无PVI与结外扩展（ENE）之间存在统计学显著关联（p = 0.035）。
PVI在不同类型癌症中的具体作用尚未阐明。我们的研究结果表明，PVI与肿瘤大小、组织学分级、LVI、PNI和ENE显著相关，而这些都是乳腺癌中众所周知的不良预后因素。PVI的存在是乳腺癌研究中一个有前景的课题，病理报告中的PVI状态可能有助于肿瘤学家对乳腺癌患者进行更好的风险评估。
