Kim Sahng G
Division of Endodontics, Columbia University College of Dental Medicine, New York, NY 10032, USA.
Biomimetics (Basel). 2024 Dec 18;9(12):771. doi: 10.3390/biomimetics9120771.
The dehydrated human amnion-chorion membranes (dHACMs) derived from the human placenta have emerged as a promising biomaterial for dental pulp regeneration owing to their unique biological and structural properties. The purpose of this review is to explore the potentials of dHACMs in dental pulp tissue engineering, focusing on their ability to promote cellular proliferation, differentiation, angiogenesis, and neurogenesis. dHACMs are rich in extracellular matrix proteins and growth factors such as TGF-β1, FGF2, and VEGF. They also exhibit significant anti-inflammatory and antimicrobial properties, creating an optimal environment for dental pulp regeneration. The applications of dHACMs in regenerative endodontic procedures are discussed, highlighting their ability to support the formation of dentin and well-vascularized pulp-like tissue. This review demonstrates that dHACMs hold significant potential for enhancing the success of pulp regeneration and offer a biologically based approach to preserve tooth vitality and improve tooth survival. Future research is expected to focus on conducting long-term clinical studies to establish their efficacy and safety.
源自人胎盘的脱水人羊膜-绒毛膜（dHACM）因其独特的生物学和结构特性，已成为一种有前景的用于牙髓再生的生物材料。本综述的目的是探讨dHACM在牙髓组织工程中的潜力，重点关注其促进细胞增殖、分化、血管生成和神经发生的能力。dHACM富含细胞外基质蛋白和生长因子，如转化生长因子-β1（TGF-β1）、成纤维细胞生长因子2（FGF2）和血管内皮生长因子（VEGF）。它们还具有显著的抗炎和抗菌特性，为牙髓再生创造了最佳环境。讨论了dHACM在再生性牙髓治疗程序中的应用，突出了其支持牙本质形成和良好血管化的牙髓样组织形成的能力。本综述表明，dHACM在提高牙髓再生成功率方面具有巨大潜力，并提供了一种基于生物学的方法来维持牙齿活力和提高牙齿留存率。未来的研究预计将集中于进行长期临床研究以确定其有效性和安全性。
