Kim David, Kim Sahng G
Center for Dental and Craniofacial Research, Columbia University College of Dental Medicine, New York, NY 10032, USA.
Division of Endodontics, Columbia University College of Dental Medicine, New York, NY 10032, USA.
Cells. 2025 Jan 29;14(3):201. doi: 10.3390/cells14030201.
Cell homing, a process that leverages the body's natural ability to recruit cells and repair damaged tissues, presents a promising alternative to cell transplantation methods. Central to this approach is the recruitment of endogenous stem/progenitor cells-such as those from the apical papilla, bone marrow, and periapical tissues-facilitated by chemotactic biological cues. Moreover, biomaterial scaffolds embedded with signaling molecules create supportive environments, promoting cell migration, adhesion, and differentiation for the regeneration of the pulp-dentin complex. By analyzing in vivo animal studies using cell homing strategies, this review explores how biomolecules and scaffold materials enhance the recruitment of endogenous stem cells to the site of damaged dental pulp tissue, thereby promoting repair and regeneration. It also examines the key principles, recent advancements, and current limitations linked to cell homing-based regenerative endodontic therapy, highlighting the interplay of biomaterials, signaling molecules, and their broader clinical implications.
细胞归巢是一种利用人体自然能力招募细胞并修复受损组织的过程，它为细胞移植方法提供了一种有前景的替代方案。这种方法的核心是通过趋化生物信号促进内源性干/祖细胞（如来自根尖乳头、骨髓和根尖周组织的细胞）的募集。此外，嵌入信号分子的生物材料支架创造了支持性环境，促进细胞迁移、黏附和分化，以实现牙髓-牙本质复合体的再生。通过分析使用细胞归巢策略的体内动物研究，本综述探讨了生物分子和支架材料如何增强内源性干细胞向受损牙髓组织部位的募集，从而促进修复和再生。它还研究了与基于细胞归巢的再生性牙髓治疗相关的关键原则、最新进展和当前局限性，强调了生物材料、信号分子之间的相互作用及其更广泛的临床意义。
