Saraswathi Karuvel Kannan, Saini Pragya, Santhi Radhakrishnan, Muthukkaruppan Veerappan, Vanniarajan Ayyasamy, Kim Usha
Department of Molecular Genetics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Department of Molecular Biology, Aravind Medical Research Foundation - Affiliated to Alagappa University, Karaikudi, Tamil Nadu, India.
Indian J Ophthalmol. 2025 Feb 1;73(2):261-266. doi: 10.4103/IJO.IJO_110_24. Epub 2024 Dec 27.
This study aims to comprehensively characterize the clinical, demographic, and histopathological features of ocular adnexal lymphoma (OAL) and assess their impact on patients' survival outcomes.
A total of 123 patients were included in the study; of these, 93 patients were selected for survival analysis. Survival data were analyzed using the Kaplan-Meier test, and correlation was assessed through the log-rank test and Cox regression analysis.
The median age at presentation was 56 years. Furthermore, 98% of patients had primary OAL. The orbit was the most common site of involvement. The majority of patients were of B-cell origin (98%), and only 2% of patients had T-cell lymphoma. In addition, 83% of patients were treated with chemotherapy, and with a median follow-up of 38 months, complete remission was achieved in 48% of patients. The median progression-free survival was 26.4 months. The presence of disseminated disease was strongly linked to an unfavorable prognosis ( P < 0.001) and reduced survival ( P = 0.037).
The 5-year overall survival of the entire study cohort was 81%. The prognosis for OAL is found to be favorable, but the presence of dissemination serves as a notable predictor for poor prognosis.
本研究旨在全面描述眼附属器淋巴瘤（OAL）的临床、人口统计学和组织病理学特征，并评估其对患者生存结果的影响。
本研究共纳入123例患者；其中93例患者被选入生存分析。生存数据采用Kaplan-Meier检验进行分析，并通过对数秩检验和Cox回归分析评估相关性。
发病时的中位年龄为56岁。此外，98%的患者患有原发性OAL。眼眶是最常见的受累部位。大多数患者起源于B细胞（98%），只有2%的患者患有T细胞淋巴瘤。此外，83%的患者接受了化疗，中位随访38个月，48%的患者实现了完全缓解。中位无进展生存期为26.4个月。疾病播散的存在与不良预后（P<0.001）和生存降低（P=0.037）密切相关。
整个研究队列的5年总生存率为81%。发现OAL的预后良好，但疾病播散的存在是不良预后的显著预测因素。
