Ferreira Kariny Realino do Rosário, Macedo Maria de Cássia Souza, Alves Ana Luiza Guimarães, Esquírio Arthur Ferreira, Botim Bianca Rossi, Jacob Gabrielly Souza, Dos Santos Mayra Evelise Cunha, Gama Gabriela Lopes, Barbosa Michelle Cristina Sales Almeida, Barbosa Alexandre Wesley Carvalho
Laboratory of Non-Invasive Neuromodulation-LANN, Department of Physical Therapy, Federal University of Juiz de Fora, Av. Moacir Paleta 1167, São Pedro, Governador Valadares 36036-900, MG, Brazil.
NeuroSci. 2024 Dec 2;5(4):614-622. doi: 10.3390/neurosci5040043.
This study aimed to assess the immediate effects of transcutaneous spinal direct current stimulation (tsDCS) on pain outcomes, measured using the visual analog scale (VAS) and pressure pain thresholds in a cohort of 55 participants experiencing chronic pain using a controlled, randomized trial with 55 participants allocated into 2 groups: 2 mA and 0.5 mA of tsDCS for 20 min. Anodal stimulation was applied on the 12th thoracic vertebra, with the cathode positioned on the 7th cervical vertebra. Pain outcomes were assessed before and post intervention using the VAS and pressure algometry. Between- and within-group differences, along with chi-square tests, were used to determine the differences and responsiveness. Significance was established at < 0.05. Findings showed significant temporal effects for both VAS ( < 0.001) and pressure algometry ( = 0.04). However, no between-group differences were noted for the time × group factor for VAS ( = 0.46) and pressure algometry ( = 0.78). No significant between-group differences were observed for the responsiveness analysis. The results indicate that a single 20-min session of 2 and 0.5 mA tsDCS improves pain scores for both intensities equally. However, there were no statistically significant between-group differences in pain perception or pressure pain threshold.
本研究旨在通过一项对照随机试验，评估经皮脊髓直流电刺激（tsDCS）对55名慢性疼痛患者疼痛结果的即时影响，采用视觉模拟量表（VAS）和压力痛阈进行测量。55名参与者被分为两组：分别接受2 mA和0.5 mA的tsDCS刺激20分钟。阳极刺激施加于第12胸椎，阴极置于第7颈椎。在干预前后使用VAS和压力痛觉测定法评估疼痛结果。组间和组内差异以及卡方检验用于确定差异和反应性。显著性设定为<0.05。结果显示，VAS（<0.001）和压力痛觉测定法（=0.04）均有显著的时间效应。然而，VAS的时间×组因素（=0.46）和压力痛觉测定法（=0.78）在组间未发现差异。反应性分析未观察到显著的组间差异。结果表明，单次20分钟的2 mA和0.5 mA tsDCS刺激对两种强度的疼痛评分改善程度相同。然而，在疼痛感知或压力痛阈方面，组间没有统计学上的显著差异。
