Andrei Corina, Nitulescu George Mihai, Nitulescu Georgiana, Zanfirescu Anca
Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia 6, 020956 Bucharest, Romania.
Pharmacy (Basel). 2024 Nov 25;12(6):176. doi: 10.3390/pharmacy12060176.
In recent years, the European market, including Romania, has witnessed a significant increase in the promotion of cannabidiol (CBD)-based products, often presented as effective treatments for various health conditions. This study investigates the inconsistencies between the health claims associated with these supplements and the evidence from clinical trials. To identify products available on the Romanian market, a systematic review of online pharmacies and websites that specialize in selling CBD-based products has been performed. Additionally, a systematic review of clinical trials has been conducted to assess the efficacy of CBD for the specified indications. Our analysis revealed that some claims, such as those related to post-traumatic stress disorder, lack substantial clinical evidence. Moreover, even when clinical support exists, the dosages recommended for the supplements are often significantly lower than those used in trials, raising concerns about their efficacy. These findings highlight the need for stricter regulatory oversight and more transparent communication to ensure that consumer expectations are aligned with scientific evidence, ultimately promoting informed decision-making and consumer safety.
近年来,包括罗马尼亚在内的欧洲市场见证了以大麻二酚(CBD)为基础的产品推广显著增加,这些产品常被宣称对各种健康状况有有效治疗作用。本研究调查了与这些补充剂相关的健康声明与临床试验证据之间的不一致性。为了确定罗马尼亚市场上可获得的产品,我们对专门销售基于CBD产品的在线药店和网站进行了系统回顾。此外,还对临床试验进行了系统回顾,以评估CBD对特定适应症的疗效。我们的分析表明,一些声明,如与创伤后应激障碍相关的声明,缺乏大量临床证据。此外,即使有临床支持,补充剂推荐的剂量通常也远低于试验中使用的剂量,这引发了对其疗效的担忧。这些发现凸显了加强监管监督和更透明沟通的必要性,以确保消费者期望与科学证据一致,最终促进明智决策和消费者安全。