二烯丙基亚硝胺对大鼠鼻腔肿瘤的选择性诱导作用
Selective induction of nasal cavity tumors in rats by diallylnitrosamine.
作者信息
Pour P M, Grandjean C J, Knepper S
出版信息
J Cancer Res Clin Oncol. 1985;109(1):5-8. doi: 10.1007/BF01884247.
Abstract
Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.
摘要
每周给BD IX大鼠胃内注射20、40和80毫克/千克体重的二烯丙基亚硝胺，可选择性地诱发鼻腔和鼻窦肿瘤，雌性大鼠的发病率分别为30%、85%和65%，雄性大鼠的发病率分别为0%、75%和80%。所有肿瘤均为嗅区癌，95%为浸润性癌。仅在前部区域发现少数乳头状瘤与癌同时存在。
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