Files Rita, Cardoso Cláudia, Prada Justina, Silva Filipe, Pires Isabel
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Vet Sci. 2024 Dec 14;11(12):652. doi: 10.3390/vetsci11120652.
Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure. Identifying new biomarkers, such as syndecan-1 (CD138) and E-cadherin, is fundamental for tumor diagnosis and prognosis. Dysregulation of syndecan-1, expressed in epithelial tissue, fibroblasts, and plasma cells, is associated with poor prognosis in several types of cancer. Similarly, E-cadherin, which plays a crucial role in cell adhesion and epithelial functionality, is also linked to adverse outcomes. This study evaluated the expression of syndecan-1 and E-cadherin in 47 cases of canine cutaneous squamous cell carcinoma. The results showed that the intensity of syndecan-1 decreased with increasing tumor aggressiveness, and its presence in the stroma was significantly associated with tumor grade. E-cadherin also demonstrated a decrease in intensity with increasing malignancy. However, the association between syndecan-1 and E-cadherin was not statistically significant. E-cadherin reduction and stromal syndecan-1 positivity seem to be associated with tumor aggressiveness in canine cutaneous squamous cell carcinoma. Further studies are needed to explore their roles in tumor progression.
犬皮肤鳞状细胞癌（CSCC）是一种局部浸润性肿瘤，通常发生在因阳光照射而色素沉着不良的皮肤区域。识别新的生物标志物，如Syndecan-1（CD138）和E-钙黏蛋白，对于肿瘤的诊断和预后至关重要。Syndecan-1在上皮组织、成纤维细胞和浆细胞中表达，其失调与几种类型癌症的不良预后相关。同样，在细胞黏附和上皮功能中起关键作用的E-钙黏蛋白也与不良结果有关。本研究评估了47例犬皮肤鳞状细胞癌中Syndecan-1和E-钙黏蛋白的表达。结果显示，Syndecan-1的强度随肿瘤侵袭性增加而降低，其在基质中的存在与肿瘤分级显著相关。E-钙黏蛋白的强度也随恶性程度增加而降低。然而，Syndecan-1与E-钙黏蛋白之间的关联无统计学意义。E-钙黏蛋白减少和基质Syndecan-1阳性似乎与犬皮肤鳞状细胞癌的肿瘤侵袭性有关。需要进一步研究以探索它们在肿瘤进展中的作用。
