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牛轮状病毒A和牛冠状病毒引起的牛急性胃肠炎的比较研究

Comparative Insights into Acute Gastroenteritis in Cattle Caused by Bovine Rotavirus A and Bovine Coronavirus.

作者信息

Kostanić Vjekoslava, Kunić Valentina, Prišlin Šimac Marina, Lolić Marica, Sukalić Tomislav, Brnić Dragan

机构信息

Department of Virology, Croatian Veterinary Institute, 10000 Zagreb, Croatia.

Laboratory for Diagnostics, Croatian Veterinary Institute, 32100 Vinkovci, Croatia.

出版信息

Vet Sci. 2024 Dec 21;11(12):671. doi: 10.3390/vetsci11120671.

Abstract

Acute gastroenteritis (AGE) in cattle significantly impacts the economy due to relatively high morbidity and mortality and decreased production. Its multifactorial nature drives its global persistence, involving enteric viruses, bacteria, protozoa, and environmental factors. Bovine (BoRVA) and bovine coronavirus (BCoV) are among the most important enteric RNA viruses causing AGE in cattle. These viruses infect intestinal enterocytes, leading to cell damage and consequently to malabsorption and diarrhea. BoRVA primarily affects calves under 14 days old with gastrointestinal clinical signs, while BCoV affects all ages, causing gastrointestinal and respiratory distress. The economic impact of BoRVA and BCoV, along with their interspecies transmission potential, warrants attention. This concise review discusses the molecular structure, epidemiology, pathogenesis, clinical signs, diagnosis, treatment, and preventive measures of BoRVA and BCoV while providing a comparative analysis. By offering practical guidance on managing such viral infections in cattle, these comparative insights may prove valuable for veterinarians in clinical practice.

摘要

牛急性胃肠炎(AGE)由于发病率和死亡率相对较高以及产量下降,对经济有重大影响。其多因素性质导致它在全球持续存在,涉及肠道病毒、细菌、原生动物和环境因素。牛轮状病毒A(BoRVA)和牛冠状病毒(BCoV)是引起牛急性胃肠炎的最重要的肠道RNA病毒。这些病毒感染肠道肠上皮细胞,导致细胞损伤,进而引起吸收不良和腹泻。BoRVA主要影响14日龄以下出现胃肠道临床症状的犊牛,而BCoV影响所有年龄段的牛,引起胃肠道和呼吸窘迫。BoRVA和BCoV的经济影响及其种间传播潜力值得关注。本简要综述讨论了BoRVA和BCoV的分子结构、流行病学、发病机制、临床症状、诊断、治疗和预防措施,并进行了比较分析。通过提供关于牛此类病毒感染管理的实用指导,这些比较见解可能对临床实践中的兽医有价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2a7/11680284/2a0ad812e818/vetsci-11-00671-g001.jpg

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