12周力量训练对行动受限老年人骨骼的影响：随机对照试验
Effects of 12-week power training on bone in mobility-limited older adults: randomised controlled trial.
作者信息
Muollo Valentina, Hvid Lars G, Shanbhogue Vikram V, Steinhauser Viktoria, Caporossi Daniela, Dimauro Ivan, Andersen Marianne Skovsager, Fantini Cristina, Grazioli Elisa, Strotmeyer Elsa S, Caserotti Paolo
机构信息
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Department of Public Health, Exercise Biology, Aarhus University, Aarhus C, Denmark.
出版信息
Arch Osteoporos. 2024 Dec 27;20(1):5. doi: 10.1007/s11657-024-01487-z.
UNLABELLED
This study examines how power training affects estimated bone strength, revealing that females benefit more than males, especially in the upper limbs (radius). These findings highlight the importance of designing sex-specific exercise programs to enhance bone health. Further research is needed to optimize training duration and address site-specific differences.
PURPOSE
This study aimed to compare the effects of 12-week of power training (PWT), an explosive form of strength training, on bone microarchitecture, estimated bone strength, and markers in mobility-limited (gait speed < 0.9 m/s) older adults.
METHODS
Fifty-seven older adults (83 ± 5 years) were randomly assigned to either a training group (TRAIN, n = 28, 15 females, 13 males) performing high-intensity PWT or a control group (CTRL, n = 29, 22 females, 7 males) maintaining their usual lifestyle. High-resolution peripheral quantitative computed tomography (HR-pQCT) assessed bone geometry, densities, microarchitecture (e.g. trabecular number (Tb.N) and thickness (Tb.Th)), and estimated bone strength (stiffness and failure load) at the tibia and radius. Blood markers for bone metabolism (PINP and CTX-1) and muscle strength (handgrip and leg press) were also measured.
RESULTS
Baseline sex differences showed females having lower stiffness (- 37.5%) and failure load (- 38%) at the radius compared with males. After PWT, females in the TRAIN group exhibited declines in Tb.N (- 4.4%) and improvements in Tb.Th (+ 6.0%), stiffness (+ 2.7%), and failure load (+ 2.4%) at the radius (p < 0.05). A time x group interaction indicated increases in leg press strength for the whole TRAIN group (+ 23%), and within females (+ 29%) and males (+ 19%) (p < 0.001). Baseline handgrip strength correlated with stiffness (r = 0.577) and failure load (r = 0.612) at the radius (p < 0.001). Females in the TRAIN group showed a reduction in PINP (- 25%), while males showed an increase in CTX-1 (+ 18%).
CONCLUSION
A 12-week PWT may enhance estimated bone strength in mobility-limited older adults, especially at sites less accustomed to daily loading (i.e. radius).
CLINICAL TRIAL REGISTRATION
NCT02051725.
未标注
本研究探讨了力量训练如何影响估计的骨强度，发现女性比男性受益更多，尤其是在上肢（桡骨）。这些发现凸显了设计针对性别的运动计划以增强骨骼健康的重要性。需要进一步研究来优化训练时长并解决特定部位的差异。
目的
本研究旨在比较为期12周的力量训练（PWT），一种爆发性的力量训练形式，对行动受限（步速＜0.9米/秒）的老年人的骨微结构、估计骨强度和标志物的影响。
方法
57名老年人（83±5岁）被随机分为训练组（TRAIN，n = 28，15名女性，13名男性），进行高强度PWT，或对照组（CTRL，n = 29，22名女性，7名男性），保持其通常的生活方式。高分辨率外周定量计算机断层扫描（HR-pQCT）评估胫骨和桡骨的骨几何形状、密度、微结构（如小梁数量（Tb.N）和厚度（Tb.Th））以及估计骨强度（刚度和破坏载荷）。还测量了骨代谢（PINP和CTX-1）和肌肉力量（握力和腿举）的血液标志物。
结果
基线时的性别差异显示，与男性相比，女性桡骨的刚度（-37.5%）和破坏载荷（-38%）较低。PWT后，训练组中的女性桡骨的Tb.N下降（-4.4%），Tb.Th增加（+6.0%），刚度增加（+2.7%），破坏载荷增加（+2.4%）（p＜0.05）。时间×组间交互作用表明，整个训练组的腿举力量增加（+23%），女性（+29%）和男性（+19%）均增加（p＜0.）。基线握力与桡骨的刚度（r = 0.577）和破坏载荷（r = 0.612）相关（p＜0.001）。训练组中的女性PINP降低（-25%），而男性的CTX-1增加（+18%）。
结论
为期12周的PWT可能会增强行动受限的老年人的估计骨强度，尤其是在较少承受日常负荷的部位（即桡骨）。
临床试验注册
NCT02051725。
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