Washist Regan, Steventon Dan, Samuelson Paige, Anderson Brittany, Berg-Poppe Patti, Milanovich Samuel
University of North Dakota School of Medicine, Department of Pediatrics, Grand Forks, North Dakota (Ms Washist and Dr Milanovich); Sanford Children's Hospital, Department of Physical Therapy, Sioux Falls, South Dakota (Dr Steventon); Sanford Children's Hospital, Department of Physical Therapy, Fargo, North Dakota (Dr Samuelson); Jamestown University, Department of Physical Therapy, Jamestown, North Dakota (Dr Anderson); University of South Dakota, Department of Physical Therapy, Vermillion, South Dakota (Dr Berg-Poppe); and Sanford Roger Maris Cancer Center, Department of Pediatric Hematology and Oncology, Fargo, North Dakota (Dr Milanovich).
Pediatr Phys Ther. 2025 Jan 1;37(1):57-63. doi: 10.1097/PEP.0000000000001156. Epub 2024 Dec 24.
Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) with associated weakness, areflexia, neuropathic pain, and sensory loss, is a common occurrence in children treated for cancer. However, accurate, quantifiable descriptions of gait deviations due to CIPN are lacking. This scoping review explores common gait abnormalities in children with CIPN.
Using extensive database and manual literature reviews, 3 relevant studies were identified that assessed CIPN-related gait changes in children.
Though each study used different methods to analyze gait patterns, decreased ankle dorsiflexion with slower and shorter gait were common findings across the studies. Changes to ankle dorsiflexion range of motion can lead to slower walking speeds and compensatory changes that can cause developmental effects on a child's gait.
Relevant research on the topic of CIPN-related gait abnormalities in children with cancer identifies knowledge gaps and the need for more studies on the effects of CIPN on children.
目的：化疗引起的周围神经病变（CIPN）伴有相关的无力、反射消失、神经性疼痛和感觉丧失，在接受癌症治疗的儿童中很常见。然而，目前缺乏对CIPN导致的步态偏差的准确、可量化描述。本范围综述探讨了CIPN患儿常见的步态异常。
通过广泛的数据库和人工文献综述，确定了3项评估儿童CIPN相关步态变化的相关研究。
尽管每项研究使用不同的方法来分析步态模式，但在各项研究中，常见的发现是踝关节背屈减少，步态更慢、更短。踝关节背屈活动范围的变化会导致步行速度减慢和代偿性变化，从而可能对儿童步态产生发育影响。
关于癌症患儿CIPN相关步态异常这一主题的相关研究揭示了知识空白，以及对CIPN对儿童影响进行更多研究的必要性。
