Abdulla Mohamed, Abdulla Maryam, Al-Hashimi Hakima, Isa Hasan M, Dunne Kevin, Blackwell James
School of Medicine, RCSI Medical University of Bahrain, Busaiteen, Bahrain.
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Pediatr Transplant. 2025 Feb;29(1):e70010. doi: 10.1111/petr.70010.
Pediatric liver transplantation (PLT) is a life-saving procedure for children with end-stage liver disease. However, post-transplant monitoring, particularly the diagnosis and prognosis of complications such as allograft fibrosis, remains challenging. Traditionally, liver biopsy has been the gold standard for assessing allograft fibrosis, despite its invasive nature and inherent procedural risks. Recently, shear wave ultrasound elastography (SWE) has seen increasing use as a noninvasive method to provide real-time, quantitative measurements of liver stiffness as a proxy for fibrosis. In this review, the latest developments in the use of SWE as a method to assess allograft fibrosis post-PLT are presented, including the current technical challenges associated with its clinical implementation.
小儿肝移植（PLT）是终末期肝病患儿的一种挽救生命的手术。然而，移植后监测，尤其是同种异体肝移植纤维化等并发症的诊断和预后评估，仍然具有挑战性。传统上，肝活检一直是评估同种异体肝移植纤维化的金标准，尽管其具有侵入性且存在固有的操作风险。最近，剪切波超声弹性成像（SWE）作为一种非侵入性方法越来越多地被用于实时、定量测量肝脏硬度，以此作为纤维化的替代指标。在这篇综述中，介绍了SWE作为评估小儿肝移植术后同种异体肝移植纤维化方法的最新进展，包括其临床应用目前面临的技术挑战。
