Carlson H E, Wasser H L, Reidelberger R D
J Clin Endocrinol Metab. 1985 Apr;60(4):673-7. doi: 10.1210/jcem-60-4-673.
Salsolinol is a tetrahydroisoquinoline compound with opiate agonist and dopamine antagonist properties. The role of salsolinol, a minor constituent of beer, in beer-induced PRL secretion was investigated in humans and rats. Beer-stimulated PRL release was greater in women than in men; the PRL-stimulating effect of beer was not blocked by naloxone pretreatment. Administration of a solution of salsolinol or cocoa (another salsolinol-containing beverage) did not stimulate PRL secretion in normal women. In rats, administration of large doses of salsolinol ip or iv was required to raise serum PRL levels, and high concentrations of salsolinol were needed to antagonize the PRL-suppressive effects of dopamine in vitro. We conclude that salsolinol is not responsible for PRL secretion induced by beer ingestion.
去甲猪毛菜酚是一种具有阿片类激动剂和多巴胺拮抗剂特性的四氢异喹啉化合物。研究了啤酒中的微量成分去甲猪毛菜酚在啤酒诱导的催乳素分泌中的作用，实验对象包括人类和大鼠。啤酒刺激引起的催乳素释放量女性高于男性；纳洛酮预处理并未阻断啤酒对催乳素的刺激作用。给正常女性注射去甲猪毛菜酚溶液或可可（另一种含去甲猪毛菜酚的饮料）不会刺激催乳素分泌。在大鼠中，需要腹腔注射或静脉注射大剂量的去甲猪毛菜酚才能提高血清催乳素水平，并且在体外需要高浓度的去甲猪毛菜酚才能拮抗多巴胺对催乳素的抑制作用。我们得出结论，摄入啤酒诱导的催乳素分泌并非由去甲猪毛菜酚引起。
