Andersen Therese M, Andersen Astrid M, Riemenschneider Morten, Taul-Madsen Laurits, Diechmann Mette, Gaemelke Tobias, Dalgas Ulrik, Brønd Jan Christian, Hvid Lars G
Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Mult Scler Relat Disord. 2025 Jan;93:106243. doi: 10.1016/j.msard.2024.106243. Epub 2024 Dec 19.
Multiple sclerosis has a substantial negative impact on physical activity (PA). However, limited knowledge exists on objectively measured PA levels and types across disability status along with its influence on walking capacity.
To (1) determine PA levels/types in persons with MS (pwMS) (overall and across disability status) and in healthy controls (HC), and (2) investigate the association between PA levels/types and walking capacity.
In this study (n = 280 pwMS, n = 118 HC), pwMS were stratified into subgroups based on the Expanded Disability Status Scale (EDSS): no disability (EDSS 0-1.5), mild (EDSS 2-2.5), moderate (EDSS 3-4.5), and severe (EDSS 5-6.5). PA levels/types were assessed by thigh-worn accelerometry and walking capacity by 2-min Walk Test (2MWT), Six Spot Step Test (SSST), and Timed 25-foot Walk Test (T25FWT). Simple and multiple linear regression analyses were used to investigate associations between PA levels/types and walking capacity in pwMS.
PA levels/types and walking capacity differed (p < 0.05) between HC and pwMS, and this was especially pronounced for counts per minute (CPM) (774±297 vs. 518±261), sedentary time (558±59 vs. 588±82 min), moderate-to-vigorous physical activity (MVPA) (47±26 vs. 27±22 min), and walking (94±33 vs. 75±38 min) with differences being accentuated with advanced disability. PA levels/types were associated with walking capacity (p < 0.001, r = 0.04-0.31), which remained after adjusting for age, sex, Body Mass Index (BMI), EDSS, and time since diagnosis (r = 0.42-0.57). Importantly, certain PA levels outcomes (light PA (LPA) and moderate-to-vigorous PA (MVPA)) and PA types outcomes (walking) were independently associated with walking capacity.
The present cross-sectional study observed that PA levels and types were negatively impacted in pwMS compared to HC, especially with advanced disability status. Furthermore, PA levels (LPA and MVPA in particular) and PA types (walking in particular) were associated with walking capacity, independently of age, sex, BMI, and disability status.
多发性硬化症对身体活动（PA）有重大负面影响。然而，关于不同残疾状态下客观测量的身体活动水平和类型及其对步行能力的影响，目前了解有限。
（1）确定多发性硬化症患者（pwMS）（总体及不同残疾状态）和健康对照者（HC）的身体活动水平/类型；（2）研究身体活动水平/类型与步行能力之间的关联。
在本研究中（n = 280名pwMS，n = 118名HC），根据扩展残疾状态量表（EDSS）将pwMS分为亚组：无残疾（EDSS 0 - 1.5）、轻度（EDSS 2 - 2.5）、中度（EDSS 3 - 4.5）和重度（EDSS 5 - 6.5）。通过佩戴在大腿上的加速度计评估身体活动水平/类型，通过2分钟步行测试（2MWT）、六点步测试（SSST）和定时25英尺步行测试（T25FWT）评估步行能力。使用简单和多元线性回归分析来研究pwMS中身体活动水平/类型与步行能力之间的关联。
HC和pwMS之间的身体活动水平/类型及步行能力存在差异（p < 0.05），这在每分钟计数（CPM）（774±297对518±261）、久坐时间（558±59对588±82分钟）、中度至剧烈身体活动（MVPA）（47±26对27±22分钟）和步行（94±33对75±38分钟）方面尤为明显，且随着残疾程度加重差异更为显著。身体活动水平/类型与步行能力相关（p < 0.001，r = 0.04 - 0.31），在调整年龄、性别、体重指数（BMI）、EDSS和诊断后的时间后，这种相关性仍然存在（r = 0.42 - 0.57）。重要的是，某些身体活动水平结果（轻度身体活动（LPA）和中度至剧烈身体活动（MVPA））和身体活动类型结果（步行）与步行能力独立相关。
本横断面研究观察到，与HC相比，pwMS的身体活动水平和类型受到负面影响，尤其是在残疾程度较高的情况下。此外，身体活动水平（特别是LPA和MVPA）和身体活动类型（特别是步行）与步行能力相关，独立于年龄、性别、BMI和残疾状态。
