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SNRK tames mTOR against metabolic dysfunction-associated steatotic liver disease.

作者信息

Brunetti-Pierri Nicola, Bewersdorf Lisa, Strnad Pavel

机构信息

Department of Translational Medicine, Federico II University, Naples, Italy; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy; Genomics and Experimental Medicine Program, Scuola Superiore Meridionale (SSM, School of Advanced Studies), Naples, Italy.

Medical Clinic III, Gastroenterology, Metabolic Diseases, and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.

出版信息

Mol Ther. 2025 Jan 8;33(1):28-29. doi: 10.1016/j.ymthe.2024.12.031. Epub 2024 Dec 26.

DOI:10.1016/j.ymthe.2024.12.031
PMID:39729984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11764957/
Abstract
摘要

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本文引用的文献

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Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH).代谢功能障碍相关脂肪性肝炎（MASH）的治疗前景
Nat Rev Drug Discov. 2025 Mar;24(3):171-189. doi: 10.1038/s41573-024-01084-2. Epub 2024 Nov 28.
2
SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD.丝氨酸/苏氨酸蛋白激酶相关激酶（SNRK）调节mTOR-自噬途径以维持非酒精性脂肪性肝病（MAFLD）中的肝脏脂质稳态。
Mol Ther. 2025 Jan 8;33(1):279-296. doi: 10.1016/j.ymthe.2024.11.016. Epub 2024 Nov 9.
3
A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics.呼吁调整基于T细胞受体疗法的人类白细胞抗原（HLA）检测监管。
Nat Rev Drug Discov. 2024 Jan;23(1):1-2. doi: 10.1038/d41573-023-00189-4.
4
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.多学会专家组关于新的脂肪肝疾病命名的德尔菲共识声明。
J Hepatol. 2023 Dec;79(6):1542-1556. doi: 10.1016/j.jhep.2023.06.003. Epub 2023 Jun 24.
5
Rare ATG7 genetic variants predispose patients to severe fatty liver disease.罕见的 ATG7 基因突变使患者易患严重的脂肪肝疾病。
J Hepatol. 2022 Sep;77(3):596-606. doi: 10.1016/j.jhep.2022.03.031. Epub 2022 Apr 9.
6
mTOR at the nexus of nutrition, growth, ageing and disease.mTOR 在营养、生长、衰老和疾病的交汇点。
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203. doi: 10.1038/s41580-019-0199-y. Epub 2020 Jan 14.
7
Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue.PP2A-Akt 相互作用失调导致脂肪组织中蔗糖非发酵相关激酶（SNRK）缺乏诱导的胰岛素抵抗。
Mol Metab. 2019 Oct;28:26-35. doi: 10.1016/j.molmet.2019.07.009. Epub 2019 Aug 2.
8
Autophagy in liver diseases: Time for translation?肝脏疾病中的自噬：是否到了转化的时机？
J Hepatol. 2019 May;70(5):985-998. doi: 10.1016/j.jhep.2019.01.026. Epub 2019 Jan 31.
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Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap.自噬通过控制 Yap 的降解来充当肝分化和癌变的守门员。
Nat Commun. 2018 Nov 23;9(1):4962. doi: 10.1038/s41467-018-07338-z.
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Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.鉴定蔗糖非发酵相关激酶（SNRK）为脂肪细胞炎症的抑制物。
Diabetes. 2013 Jul;62(7):2396-409. doi: 10.2337/db12-1081. Epub 2013 Mar 21.