Lutman Mark E, de Carpentier John, Green Kevin
Emeritus Professor of Audiology, University of Southampton, Southampton, UK.
Consultant ENT Surgeon, Lancashire Teaching Hospitals NHS Trust, Preston, UK.
Clin Otolaryngol. 2025 May;50(3):446-455. doi: 10.1111/coa.14268. Epub 2024 Dec 27.
A recent paper by Moore, Lowe and Cox has proposed guidelines for diagnosing noise-induced hearing loss (NIHL). It is referred to here as the MLC guidelines. Our aim was to assess the specificity of those guidelines (i.e., freedom from false-positive outcomes) and compare with pre-existing guidelines.
We applied the MLC guidelines and pre-existing guidelines to three data sets composed of adults who do not have a history of material noise exposure and therefore cannot have NIHL.
National Health Service (NHS) ENT clinic.
Five hundred thirty-six patients with hearing difficulty and/or tinnitus who denied material noise exposure. Two large archival population studies of hearing were also assessed, which included 3250 participants without material noise exposure.
False-positive outcome from guidelines.
The MLC guidelines demonstrated moderate or high false-positive rates overall, the magnitude depending on the noise exposure scenario and whether clinical or population samples were considered. For the procedure applicable to steady broadband noise exposure, the false-positive rate averaged 56% in the population samples, compared to 31% for previous guidelines. For exposure to intense impulse sounds, the MLC guidelines take a different approach and the false-positive rate was about 70% in the population samples and even higher in the clinic sample. For exposure to intense tones, the MLC guidelines take yet another approach and the false-positive rate reached 80%.
The MLC guidelines demonstrate poorer specificity than previous guidelines. Medical experts should be aware of their poor specificity and consequential likelihood of false-positive diagnoses of NIHL.
摩尔、洛和考克斯最近发表的一篇论文提出了诊断噪声性听力损失(NIHL)的指南。此处将其称为MLC指南。我们的目的是评估这些指南的特异性(即无假阳性结果),并与先前存在的指南进行比较。
我们将MLC指南和先前存在的指南应用于三个数据集,这些数据集由没有重大噪声暴露史且因此不可能患有NIHL的成年人组成。
国民保健服务(NHS)耳鼻喉科诊所。
536名有听力困难和/或耳鸣但否认有重大噪声暴露的患者。还评估了两项大型听力档案人群研究,其中包括3250名没有重大噪声暴露的参与者。
指南的假阳性结果。
MLC指南总体上显示出中度或高度的假阳性率,其幅度取决于噪声暴露情况以及是否考虑临床样本或人群样本。对于适用于稳定宽带噪声暴露的程序,人群样本中的假阳性率平均为56%,而先前指南为31%。对于暴露于强烈脉冲声的情况,MLC指南采用了不同的方法,人群样本中的假阳性率约为70%,在临床样本中甚至更高。对于暴露于强烈音调的情况,MLC指南又采用了另一种方法,假阳性率达到了80%。
MLC指南的特异性比先前的指南更差。医学专家应意识到其特异性较差以及NIHL假阳性诊断的相应可能性。