Woolcott Orison O, Samarasundera Edgar, Heath Alicia K
School of Public Health, Faculty of Medicine, Imperial College London, London, UK.
Institute for Globally Distributed Open Research and Education (IGDORE), Los Angeles, CA, USA.
Sci Rep. 2024 Dec 28;14(1):30823. doi: 10.1038/s41598-024-81497-6.
Although studies have examined the association of the Relative Fat Mass (RFM, a novel anthropometric index used as a surrogate for whole-body fat percentage) with all-cause mortality, the association of RFM with diabetes-related mortality and heart disease mortality has not been thoroughly investigated. In addition, no study has compared the associations of RFM and waist circumference (a surrogate for intra-abdominal fat) with cause-specific mortality and all-cause mortality. In the present study, we addressed these knowledge gaps. We used data from the US National Health and Nutrition Examination Survey (NHANES) 1999-2018. NHANES III was used for validation. Analyses included 46,535 adults (mean age 46.5 years). During a median follow-up time of 9.7 years, 6,101 participants died (743 from diabetes; 1,514 from heart disease). Compared with BMI and WC, RFM was more strongly associated with diabetes-related mortality in both women and men, adjusting for age, ethnicity, education, and smoking status. All anthropometric measures were similarly strongly associated with heart disease mortality and all-cause mortality. RFM showed greater predictive discrimination of mortality. Similar results were found in NHANES III (n = 14,448). In conclusion, RFM is strongly associated with diabetes-related mortality, heart disease mortality, and all-cause mortality, and outperforms conventional adiposity measures for prediction of mortality.
尽管已有研究探讨了相对脂肪量（RFM，一种用作全身脂肪百分比替代指标的新型人体测量指数）与全因死亡率之间的关联，但RFM与糖尿病相关死亡率和心脏病死亡率之间的关联尚未得到充分研究。此外，尚无研究比较RFM和腰围（腹内脂肪的替代指标）与特定病因死亡率和全因死亡率之间的关联。在本研究中，我们填补了这些知识空白。我们使用了1999 - 2018年美国国家健康与营养检查调查（NHANES）的数据。NHANES III用于验证。分析纳入了46,535名成年人（平均年龄46.5岁）。在中位随访时间9.7年期间，6,101名参与者死亡（743例死于糖尿病；1,514例死于心脏病）。在调整年龄、种族、教育程度和吸烟状况后，与体重指数（BMI）和腰围（WC）相比，RFM与女性和男性的糖尿病相关死亡率的关联更强。所有人体测量指标与心脏病死亡率和全因死亡率的关联同样强烈。RFM对死亡率的预测辨别力更强。在NHANES III（n = 14,448）中也发现了类似结果。总之, RFM与糖尿病相关死亡率、心脏病死亡率和全因死亡率密切相关，在预测死亡率方面优于传统的肥胖测量指标。
