Rabkin J G, Quitkin F M, McGrath P, Harrison W, Tricamo E
J Clin Psychopharmacol. 1985 Feb;5(1):2-9.
From a review of the clinical charts of 198 depressed outpatients, information was extracted on common major treatment emergent side effects associated with phenelzine, tranylcypromine, and imipramine. These included hypertensive reactions, severe orthostatic hypotension, hypomania, significant weight gain, sexual dysfunction, and a residual category of multiple side effects which together culminated in drug discontinuation. In this report, frequency of their occurrence for each drug, level of severity, relation to dose and treatment duration, and physician response at the time the side effect was recorded are described. In addition, procedures found useful in the clinical management of these side effects are discussed.
通过回顾198例门诊抑郁症患者的临床病历，提取了与苯乙肼、反苯环丙胺和丙咪嗪相关的常见主要治疗中出现的副作用信息。这些副作用包括高血压反应、严重直立性低血压、轻躁狂、显著体重增加、性功能障碍以及导致停药的多种副作用的残余类别。在本报告中，描述了每种药物副作用的发生频率、严重程度、与剂量和治疗持续时间的关系以及记录副作用时医生的应对措施。此外，还讨论了在这些副作用临床管理中发现有用的程序。
