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耐甲氧西林金黄色葡萄球菌（MRSA）治疗的进展：黄连素在增强抗生素治疗中的作用。

Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy.

作者信息

Zhou Fangfang, Gu Xuemei, Wang Wei, Lin Ming, Wang Lei

机构信息

Department of Clinical Laboratory, Shanghai Eighth People's Hospital, No.8 Caobao Road, Xuhui District, Shanghai, 200235, P.R. China.

School of Medicine, Jiangsu University, Zhenjiang, 212001, Jiangsu, P.R. China.

出版信息

BMC Microbiol. 2024 Dec 27;24(1):540. doi: 10.1186/s12866-024-03692-9.

DOI:10.1186/s12866-024-03692-9
PMID:39731013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674092/
Abstract

BACKGROUND

Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health problem. This study investigated the antimicrobial properties and mechanisms of berberine (BBR), a plant alkaloid, against MRSA, evaluating its potential to enhance antibiotic therapy.

RESULTS

Berberine only demonstrated variable but significant inhibitory effects on 50 clinical MRSA strains. When combined with antibiotics, synergistic effects were observed only with amikacin in 6 of the 50 MRSA strains. BBR disrupted MRSA cell wall integrity, leading to leakage of cellular contents. Network pharmacology analysis revealed that BBR targets multiple pathways essential for bacterial survival.

CONCLUSION

The study confirmed the potent antimicrobial activity of berberine against MRSA and its capability to act synergistically with traditional antibiotics. Berberine's impact on cell wall integrity and bacterial survival pathways highlights its potential as an adjunct therapy in MRSA treatment.

摘要

背景

耐甲氧西林金黄色葡萄球菌（MRSA）是一个重大的公共卫生问题。本研究调查了植物生物碱黄连素（BBR）对MRSA的抗菌特性及作用机制，评估其增强抗生素治疗的潜力。

结果

黄连素仅对50株临床MRSA菌株表现出不同程度但显著的抑制作用。与抗生素联合使用时，仅在50株MRSA菌株中的6株中观察到与阿米卡星有协同作用。BBR破坏了MRSA细胞壁的完整性，导致细胞内容物泄漏。网络药理学分析表明，BBR靶向细菌生存所必需的多个途径。

结论

该研究证实了黄连素对MRSA具有强大的抗菌活性及其与传统抗生素协同作用的能力。黄连素对细胞壁完整性和细菌生存途径的影响突出了其作为MRSA治疗辅助疗法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/f72266a24d40/12866_2024_3692_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/ac2e086f0b82/12866_2024_3692_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/1ad395df7559/12866_2024_3692_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/3405e5321399/12866_2024_3692_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/2a8f23ed8989/12866_2024_3692_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/0db11b94bb43/12866_2024_3692_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/f72266a24d40/12866_2024_3692_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/ac2e086f0b82/12866_2024_3692_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/1ad395df7559/12866_2024_3692_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/3405e5321399/12866_2024_3692_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/2a8f23ed8989/12866_2024_3692_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/0db11b94bb43/12866_2024_3692_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3973/11674092/f72266a24d40/12866_2024_3692_Fig6_HTML.jpg

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