Nojomi Sara, Soltanmohammadi Fatemeh, Azimi Alamdari Hamideh, Hamedyazdan Sanaz, Mahmoudi Gharehbaba Adel, Javadzadeh Yousef
Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Dermatology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cosmet Dermatol. 2025 Jan;24(1):e16734. doi: 10.1111/jocd.16734.
Skin aging is a multifaceted condition marked by the development of wrinkles, reduced suppleness, and uneven pigmentation. Both endogenous and exogenous factors contribute to skin aging. Studies have examined the possible anti-aging advantages of horsetail and soybean extracts, which are abundant in antioxidants.
A study was conducted to develop and assess the stability of an anti-wrinkle cream combining horsetail and soybean extracts over a period of 6 months. This study was a pilot study that was prospective and noncomparative in nature. An investigation was performed to explore the efficiency of a treatment on wrinkles on the forehead. The study involved 15 volunteers between the ages of 35 and 55, and the modified Fitzpatrick wrinkle grading scale (FWS) method was used to assess the results. The participants were directed to administer cream to the forehead region for a duration of eight sequential weeks. Images were acquired at the initial stage and after 8 weeks of treatment. An independent investigator evaluated the improvement in the overall appearance of the forehead skin by comparing clinical images taken before and after the therapy.
The cream exhibited exceptional stability, showing no noteworthy alterations in pH, viscosity, or microbiological count. The clinical findings demonstrated a notable decrease in the average FWS score from 8.7 ± 1.3 to 6.1 ± 1.8 (p < 0.005) after the treatment. 93.4% of the individuals experienced a positive alteration in the appearance of their forehead wrinkles.
The formulated cream presents a hopeful method to tackle skin aging issues, backed by its durability and effectiveness in diminishing wrinkles. Additional investigation is necessary to clarify the underlying mechanisms.
IRCT20190917044799N1.
皮肤老化是一种多方面的状况，其特征为皱纹的出现、柔韧性降低和色素沉着不均。内源性和外源性因素均会导致皮肤老化。已有研究探讨了富含抗氧化剂的马尾草提取物和大豆提取物可能具有的抗老化优势。
开展了一项研究，以研发并评估一款含有马尾草提取物和大豆提取物的抗皱面霜在6个月期间的稳定性。本研究为前瞻性、非对比性的试点研究。进行了一项调查，以探究一种治疗方法对前额皱纹的效果。该研究纳入了15名年龄在35至55岁之间的志愿者，并使用改良的菲茨帕特里克皱纹分级量表（FWS）方法评估结果。指导参与者在前额区域涂抹面霜，持续8周。在初始阶段和治疗8周后采集图像。一名独立研究者通过比较治疗前后拍摄的临床图像，评估前额皮肤整体外观的改善情况。
该面霜表现出卓越的稳定性，在pH值、粘度或微生物计数方面未出现显著变化。临床结果显示，治疗后平均FWS评分从8.7±1.3显著降至6.1±1.8（p<0.005）。93.4%的个体前额皱纹外观出现了积极变化。
所配制的面霜为解决皮肤老化问题提供了一种有前景的方法，其在减少皱纹方面的耐久性和有效性为此提供了支持。需要进一步研究以阐明其潜在机制。
IRCT20190917044799N1。
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