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[成人失神癫痫持续状态]

[Absence status epilepticus in adults].

作者信息

Kozhokaru A B, Vlasov P N, Karlov V A, Pushkar T N, Airapetyan A K

机构信息

Burnasyan Federal Medical Biophysical Center, Moscow, Russia.

Russian University of Medicine, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(12):47-56. doi: 10.17116/jnevro202412412147.

Abstract

Absence status epilepticus (ASE) is a type of nonconvulsive status epilepticus, in which varying grade of consciousness impairment lasting more than 15 minutes and are accompanied by constant generalized spike-wave complexes with a frequency of 2.5-4 Hz on the electroencephalogram (EEG). ASE can be observed in various epileptic syndromes, usually detected in children. In some cases, ASE manifests in adulthood as a late complication of idiopathic generalized epilepsy or status for the first time (de novo), without history of epilepsy. A review of reported cases of ASE manifestation in adulthood is presented and two of our own clinical observations of ASE that occurred in adult patients who did not have a previously established diagnosis of epilepsy are discussed. Quite clear clinical and EEG syndromic delineation of ASE in adults and the elderly, high effectivenefe of therapy and good outcome of the disease allow distinguishing recurrent ASE as a separate epileptic syndrome, in contrast to nonconvulsive status epilepticus in other neurological diseases.

摘要

失神癫痫持续状态(ASE)是一种非惊厥性癫痫持续状态,其特征为不同程度的意识障碍持续超过15分钟,并伴有脑电图(EEG)上频率为2.5 - 4Hz的持续性广泛性棘慢复合波。ASE可见于各种癫痫综合征,多见于儿童。在某些情况下,ASE在成年期表现为特发性全身性癫痫的晚期并发症或首次(新发)出现,既往无癫痫病史。本文回顾了成年期ASE表现的报道病例,并讨论了我们自己遇到的两例成年患者发生ASE的临床观察情况,这些成年患者之前未确诊癫痫。成人和老年人中ASE清晰的临床和脑电图综合征特征、治疗的高效性以及疾病的良好预后,使得复发性ASE有别于其他神经系统疾病中的非惊厥性癫痫持续状态,可作为一种单独的癫痫综合征。

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