Wang Jing-Rui, Yang Qi-Jun, Lu Bei, Cai Yang, Yin Jun-Jie
Department of Hepatobiliary Surgery, Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine, Hangzhou, China.
J Int Med Res. 2024 Dec;52(12):3000605241306649. doi: 10.1177/03000605241306649.
Epithelioid hemangioendothelioma is a low-grade malignant tumor of vascular origin. The rarity of hepatic epithelioid hemangioendothelioma (HEHE) makes the diagnosis and treatment of this entity challenging. We report a case of a 69-year-old female patient who suffered from HEHE and complained of abdominal distension pain with dizziness and appetite loss for more than half a month. Enhanced computed tomography of the upper abdomen indicated multiple space-occupying lesions in the liver. The pathological results of color ultrasound puncture suggested HEHE. We performed transcatheter arterial chemoembolization and relevant examinations according to the patient's condition and their choice. We followed the patient for 5 years and found that she developed recurrent intrahepatic metastasis of the tumor. Computed tomography was performed again after 3 months of treatment with anlotinib and the tumor did not show any progression. HEHE is a relatively rare hepatic malignant tumor derived from vascular endothelial cells, with a low incidence, atypical clinical manifestations, and a difficult diagnosis that can only be confirmed with pathological results. Currently, appropriate treatment methods should be selected according to the specific conditions of the patient.
上皮样血管内皮瘤是一种起源于血管的低度恶性肿瘤。肝上皮样血管内皮瘤（HEHE）较为罕见，这使得对该疾病的诊断和治疗具有挑战性。我们报告一例69岁女性患者，患有HEHE，主诉腹胀痛伴头晕、食欲减退超过半个月。上腹部增强计算机断层扫描显示肝脏有多个占位性病变。彩色超声穿刺病理结果提示为HEHE。我们根据患者的病情和选择进行了经导管动脉化疗栓塞及相关检查。我们对患者进行了5年的随访，发现她出现了肿瘤肝内复发转移。使用安罗替尼治疗3个月后再次进行计算机断层扫描，肿瘤未显示任何进展。HEHE是一种相对罕见的源自血管内皮细胞的肝脏恶性肿瘤，发病率低，临床表现不典型，诊断困难，只能通过病理结果确诊。目前，应根据患者的具体情况选择合适的治疗方法。
