Ramzan Hussain, Kousar Humaira, Nawaz Azeem Rab
Nishtar Medical University, Multan, Pakistan.
Int Urol Nephrol. 2025 Jun;57(6):1851-1852. doi: 10.1007/s11255-024-04352-7. Epub 2024 Dec 28.
Renal fibrosis is a hallmark of chronic kidney disease, characterized by the excessive accumulation of extracellular matrix proteins. Sulforaphane, a potent antioxidant found in cruciferous vegetables, has shown promise in targeting renal fibrosis. By inhibiting fibrotic pathways, such as TGF-β signaling, and promoting antioxidant defenses, sulforaphane may offer a novel therapeutic strategy for mitigating kidney damage and slowing disease progression. Further research is needed to fully explore its therapeutic potential.
肾纤维化是慢性肾脏病的一个标志，其特征是细胞外基质蛋白过度积聚。萝卜硫素是十字花科蔬菜中发现的一种强效抗氧化剂，已显示出在针对肾纤维化方面的前景。通过抑制纤维化途径，如转化生长因子-β信号传导，并促进抗氧化防御，萝卜硫素可能为减轻肾脏损伤和减缓疾病进展提供一种新的治疗策略。需要进一步研究以充分探索其治疗潜力。
