Cona Andrea, Luppi Mario, Kodiyanplakkal Rosy Priya, Perra Simone, Mularoni Alessandra, Malinis Maricar
Unit of Infectious Diseases, IRCCS-ISMETT Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.
Section of Hematology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Modena, Modena, Italy.
Transpl Infect Dis. 2025 Jan-Feb;27(1):e14426. doi: 10.1111/tid.14426. Epub 2024 Dec 28.
This case involves a 52-year-old male, who underwent a deceased donor orthotopic liver transplant 7 months prior, presented with a 2-week history of persistent fever, anemia, thrombocytopenia, and mild elevation of liver enzymes. Upon hospital admission, the patient was febbrile, alert and oriented, hemodynamically stable. Laboratory exams revealed worsening leukopenia, anemia, thrombocytopenia, hyponatremia, and elevated ferritin. On hospital day 5, the general condition of the patient rapidly deteriorated with dyspnea, asthenia, and worsening fever and pancytopenia.Computed tomography revealed splenomegaly and minimal bilateral pleural effusion.
该病例为一名52岁男性,7个月前接受了尸体供肝原位肝移植,出现持续发热、贫血、血小板减少和肝酶轻度升高2周。入院时,患者发热,意识清醒,定向力正常,血流动力学稳定。实验室检查显示白细胞减少、贫血、血小板减少、低钠血症加重以及铁蛋白升高。住院第5天,患者的一般状况迅速恶化,出现呼吸困难、乏力、发热加重和全血细胞减少。计算机断层扫描显示脾肿大和双侧少量胸腔积液。