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对于非急诊主动脉手术患者,目前的随访间隔合理吗?

Are current follow-up intervals justified in patients with non-emergent aortic surgeries?

作者信息

Kletzer Joseph, Berger Tim, Kondov Stoyan, Bleile Thomas, Dimov Aleksandar, Werdecker Victoria, Czerny Martin, Rylski Bartosz, Kreibich Maximilian

机构信息

Department of Cardiovascular Surgery, University Hospital Freiburg Heart Centre, Freiburg, Germany.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

出版信息

Interdiscip Cardiovasc Thorac Surg. 2024 Dec 25;40(1). doi: 10.1093/icvts/ivae226.

Abstract

OBJECTIVES

Evidence for different surveillance protocols following aortic treatment is still lacking. The aim of this study was to analyse the clinical relevance of a first follow-up visit after 6 months.

METHODS

Between January 2018 and December 2019, 464 patients treated for non-emergent aortic pathologies were retrospectively analysed. The incidence of aortic events during follow-up (ie, death, reintervention, endoleaks, anastomotic/new aneurysms and diameter progression over time) was investigated. A discrete-time non-homogeneous Markov Chain Model was used to analyse the data and to arrive at the number of skipped 6-month follow-up visits needed to harm a patient.

RESULTS

After 6 months, 2 (1.77%) patients had died, 15 (15.31%) patients suffered from aortic events and a total of 4 (3.67%) patients had undergone reintervention after endovascular surgery, compared to 0 deaths, 2 (0.59%) patients with aortic events and 5 (1.48%) reinterventions after open surgery. In our Markov Chain Model, after 6 months, 4.75% of patients showed aortic events, received a reintervention or died. Sixty patients would need to skip their 6-month follow-up visit for one indication for reintervention to go unnoticed. Only 24 would need to skip it for one complication to go by unnoticed. This number is 55 after open surgery and 9 after endovascular surgery.

CONCLUSIONS

After elective endovascular or open aortic surgery without immediate in-hospital postoperative aortic events, the first follow-up visit after 6 months is important. Extending the first interval to longer time periods might lead to a considerable increase in missed aortic events. The cost and radiation exposure of frequent follow-ups must be balanced against the benefits of early preventative aortic interventions, warranting further research.

摘要

目的

主动脉治疗后不同监测方案的证据仍然不足。本研究的目的是分析6个月后首次随访的临床相关性。

方法

回顾性分析2018年1月至2019年12月期间464例接受非急诊主动脉疾病治疗的患者。调查随访期间主动脉事件的发生率(即死亡、再次干预、内漏、吻合口/新动脉瘤以及直径随时间的进展)。使用离散时间非齐次马尔可夫链模型分析数据,并得出为使患者受到伤害而需要跳过的6个月随访次数。

结果

6个月后,2例(1.77%)患者死亡,15例(15.31%)患者发生主动脉事件,血管内手术后共有4例(3.67%)患者接受了再次干预,相比之下,开放手术后0例死亡,2例(0.59%)患者发生主动脉事件,5例(1.48%)接受再次干预。在我们的马尔可夫链模型中,6个月后,4.75%的患者出现主动脉事件、接受再次干预或死亡。60名患者需要跳过6个月的随访,才能使一次再次干预的指征未被发现。只有24名患者需要跳过随访,才能使一种并发症未被发现。开放手术后这个数字是55,血管内手术后是9。

结论

在择期血管内或开放主动脉手术后,若术后住院期间未立即发生主动脉事件,6个月后的首次随访很重要。将第一个间隔延长至更长时间可能会导致错过主动脉事件的情况大幅增加。频繁随访的成本和辐射暴露必须与早期预防性主动脉干预的益处相权衡,这值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c33/11706529/9c9d3d99094f/ivae226f7.jpg

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