Erboz Aysin, Kesekler Elif, Gentili Pier Luigi, Uversky Vladimir N, Coskuner-Weber Orkid
Molecular Biotechnology, Turkish-German University, Sahinkaya Caddesi No. 106, Beykoz, Istanbul, 34820, Turkey.
Department of Chemistry, Biology, and Biotechnology, Università degli Studi di Perugia, 06123, Perugia, Italy.
Prog Biophys Mol Biol. 2025 Mar;195:87-99. doi: 10.1016/j.pbiomolbio.2024.12.004. Epub 2024 Dec 26.
The intersection of electromagnetic radiation and neuronal communication, focusing on the potential role of biophoton emission in brain function and neurodegenerative diseases is an emerging research area. Traditionally, it is believed that neurons encode and communicate information via electrochemical impulses, generating electromagnetic fields detectable by EEG and MEG. Recent discoveries indicate that neurons may also emit biophotons, suggesting an additional communication channel alongside the regular synaptic interactions. This dual signaling system is analyzed for its potential in synchronizing neuronal activity and improving information transfer, with implications for brain-like computing systems. The clinical relevance is explored through the lens of neurodegenerative diseases and intrinsically disordered proteins, where oxidative stress may alter biophoton emission, offering clues for pathological conditions, such as Alzheimer's and Parkinson's diseases. The potential therapeutic use of Low-Level Laser Therapy (LLLT) is also examined for its ability to modulate biophoton activity and mitigate oxidative stress, presenting new opportunities for treatment. Here, we invite further exploration into the intricate roles the electromagnetic phenomena play in brain function, potentially leading to breakthroughs in computational neuroscience and medical therapies for neurodegenerative diseases.
电磁辐射与神经元通信的交叉领域，聚焦于生物光子发射在脑功能和神经退行性疾病中的潜在作用，是一个新兴的研究领域。传统上，人们认为神经元通过电化学冲动编码和传递信息，产生可被脑电图（EEG）和脑磁图（MEG）检测到的电磁场。最近的发现表明，神经元也可能发射生物光子，这意味着除了常规的突触相互作用外，还存在另一种通信渠道。本文分析了这种双重信号系统在同步神经元活动和改善信息传递方面的潜力，及其对类脑计算系统的影响。通过神经退行性疾病和内在无序蛋白质的视角探讨了其临床相关性，其中氧化应激可能会改变生物光子发射，为诸如阿尔茨海默病和帕金森病等病理状况提供线索。还研究了低强度激光疗法（LLLT）的潜在治疗用途，即其调节生物光子活动和减轻氧化应激的能力，为治疗带来了新的机会。在此，我们邀请进一步探索电磁现象在脑功能中所起的复杂作用，这可能会在计算神经科学和神经退行性疾病的医学治疗方面取得突破。
