Jauny Gwendolyn, Le Petit Marine, Segobin Shailendra, Merck Catherine, Belliard Serge, Eustache Francis, Laisney Mickael, Hinault Thomas
Normandie Univ, UNICAEN, PSL Université Paris, EPHE, Inserm, U1077, CHU de Caen, Centre Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France.
Normandie Univ, UNICAEN, PSL Université Paris, EPHE, Inserm, U1077, CHU de Caen, Centre Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France; GIGA-CRC in Vivo Imaging, University of Liège, Liège, Belgium.
Cortex. 2025 Feb;183:405-419. doi: 10.1016/j.cortex.2024.11.013. Epub 2024 Dec 16.
Healthy aging is characterized by frontal and diffuse brain changes, while certain age-related pathologies such as semantic dementia will be associated with more focal brain lesions, particularly in the temporo-parietal regions. These changes in structural integrity could influence functional brain networks. Here we use multilayer brain network analysis on structural (DWI) and functional (fMRI) data in younger and older healthy individuals and patients with semantic dementia. Relative to younger adults, results revealed lower levels of similarity of connectivity patterns between brain structure and function, and an increased network clustering in frontal regions in healthy older individuals. These changes were either associated with a preservation (similarity) and a decrease (clustering) in cognitive performance. Patients with semantic dementia showed an increase in the similarity of structural and functional connectivity patterns, as well as an increase in clustering in temporo-parietal regions. These changes were respectively associated with a preservation and a decrease in cognitive performance. These results provide a better characterization of distinct profiles of age- and pathology-brain network changes and their association with the preservation or the decline of cognitive functions.
健康衰老的特征是大脑出现额叶和弥漫性变化，而某些与年龄相关的病症，如语义性痴呆，则与更局限的脑损伤有关，尤其是在颞顶叶区域。结构完整性的这些变化可能会影响大脑功能网络。在此，我们对年轻和年长的健康个体以及语义性痴呆患者的结构（弥散加权成像，DWI）和功能（功能磁共振成像，fMRI）数据进行多层脑网络分析。相对于年轻成年人，结果显示健康年长个体的脑结构与功能之间的连接模式相似性较低，且额叶区域的网络聚类增加。这些变化分别与认知表现的保留（相似性）和下降（聚类）相关。语义性痴呆患者的结构和功能连接模式相似性增加，颞顶叶区域的聚类也增加。这些变化分别与认知表现的保留和下降相关。这些结果更好地描绘了年龄和病理相关的脑网络变化的不同特征及其与认知功能保留或衰退的关联。
