Zhao Linlin, Cui Man, Yang Saiqi, Zhou Hui, Li Meng
Health Management Medicine Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China; Health Management Research Center of Central South University, Changsha, Hunan, 410013, People's Republic of China.
Department of Medical Administration, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250001, People's Republic of China.
Nutr Metab Cardiovasc Dis. 2025 Apr;35(4):103807. doi: 10.1016/j.numecd.2024.103807. Epub 2024 Nov 23.
Prior research has established a relationship between homocysteine (Hcy) and serum uric acid (SUA) levels; however, the precise mechanisms underlying this association remain unclear. The objective of this research was to explore the correlation between SUA and Hcy and to evaluate the possible role of kidney function as a mediator in the connection between SUA and Hcy.
Consecutive enrollment of 16870 participants aged 20-60 years was conducted at the Third Xiangya Hospital of Central South University. Self-reported health questionnaires were used to gather information on health behaviors and medical backgrounds. Trained personnel performed laboratory examinations using standard methods. A mediation analysis was performed to explore the possible effect of renal function on the association between SUA and Hcy levels. Estimated glomerular filtration rate (eGFR) was used to assess kidney function. Logistic regression analysis showed that SUA levels were positively correlated with Hcy levels and hyperhomocysteinemia (HHcy) risk (p < 0.01). Subgroup analysis showed the robustness of the results. Significant mediation effects of eGFR were found in the relationship between SUA and Hcy, as demonstrated by the subsequent mediation analysis. In the overall study group, the percentage of eGFR mediated in the association between SUA and Hcy was 63.36 %, with 41.59 % and 57.59 % in women and men, respectively.
SUA was positively correlated with Hcy and HHcy risks, and the effects of SUA on Hcy may be mediated by renal function indicators (eGFR).
先前的研究已证实同型半胱氨酸（Hcy）与血清尿酸（SUA）水平之间存在关联；然而，这种关联背后的确切机制仍不清楚。本研究的目的是探讨SUA与Hcy之间的相关性，并评估肾功能作为SUA与Hcy之间联系的中介可能发挥的作用。
在中南大学湘雅三医院连续招募了16870名年龄在20至60岁之间的参与者。通过自行报告的健康问卷收集健康行为和医学背景信息。训练有素的人员采用标准方法进行实验室检查。进行中介分析以探讨肾功能对SUA与Hcy水平之间关联的可能影响。采用估计肾小球滤过率（eGFR）评估肾功能。逻辑回归分析显示，SUA水平与Hcy水平及高同型半胱氨酸血症（HHcy）风险呈正相关（p < 0.01）。亚组分析表明结果具有稳健性。后续的中介分析表明，eGFR在SUA与Hcy的关系中具有显著的中介作用。在整个研究组中，eGFR在SUA与Hcy关联中所起的中介作用百分比为63.36%，在女性和男性中分别为41.59%和57.59%。
SUA与Hcy及HHcy风险呈正相关，SUA对Hcy的影响可能由肾功能指标（eGFR）介导。
