Ye Haiyan, He Jinhui, Huang Jing, Chu Patrick, Liu Junru, Poon Rosana Wing-Shan, Xing Fanfan, Lo Simon Kam-Fai, Lau Ricky Wing-Tong, Chan Jasper Fuk-Woo, Lau Susanna Kar-Pui, Chiu Kelvin Hei-Yeung
Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Department of Hematology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Diagn Pathol. 2024 Dec 28;19(1):168. doi: 10.1186/s13000-024-01589-9.
Hormographiella aspergillata is a rare hyaline mold causing invasive fungal infection in humans, until the frequent use of antifungal prophylaxis in immunocompromised hosts. Due to the high mortality of H. aspergillata infection, early recognition and treatment are crucial. Previous case reports suggested that serum (1,3)-beta-D-Glucan (BG) is one of the diagnostic aids for H. aspergillata infection. Here we report for the first time a case of pulmonary H. aspergillata infection with a negative serum BG but positive bronchoalveolar lavage fluid (BAL) BG. This may suggest that BAL BG is a useful and additional microbiological marker for prompt identification of this fatal invasive fungal infection (IFI). But it should be interpreted together with the clinical presentation, imaging, and other laboratory results.
曲霉样拟青霉是一种罕见的透明霉菌，可引起人类侵袭性真菌感染，直到免疫功能低下宿主频繁使用抗真菌预防措施后才有所改变。由于曲霉样拟青霉感染的死亡率很高，早期识别和治疗至关重要。先前的病例报告表明，血清（1,3）-β-D-葡聚糖（BG）是曲霉样拟青霉感染的诊断辅助手段之一。在此，我们首次报告一例肺部曲霉样拟青霉感染病例，其血清BG阴性，但支气管肺泡灌洗液（BAL）BG阳性。这可能表明BAL BG是快速识别这种致命侵袭性真菌感染（IFI）的有用且额外的微生物学标志物。但它应与临床表现、影像学和其他实验室结果一起解读。
