Hu Ling, Huang Yuan-Jun, Wei You-Dong, Li Tao, Ke Wei, Chen Guang-Hui, Dong Mei-Xue
Department of Neurology, Hubei General Hospital, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
The First Branch, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Sci Rep. 2024 Dec 28;14(1):31262. doi: 10.1038/s41598-024-82674-3.
The effect of sexual dimorphism on the metabolism of patients with Parkinson's disease has not been clarified. A group of patients with Parkinson's disease and healthy controls were recruited, and their clinical characteristics and plasma were collected. Untargeted liquid chromatography-mass spectrometry-based plasma metabolomics profiling was performed. Differentially expressed metabolites between patients and healthy controls were respectively identified in the male and female participants and metabolite set enrichment analyses were further employed. A total of 75 patients with Parkinson's disease (37 males and 38 females) and 31 healthy controls (16 males and 15 females) were enrolled while no significant differences can be discovered in clinical characteristics. The constructed male-specific metabolic model from orthogonal partial least squares-discriminant analysis can't well recognize female patients and the female-specific model also can't accurately identify male patients. There were 55 differentially expressed metabolites in the male participants, and fatty acids and conjugates and eicosanoids were the significantly enriched metabolite sets. Meanwhile, 86 metabolites were differentially expressed in the female participants while fatty acids and conjugates and glycerophosphocholines were enriched. Only 17 metabolites were simultaneously changed in both male and female patients. Significant sex differences of lipid metabolism were found in patients with Parkinson's disease.
帕金森病患者的性二态性对其代谢的影响尚未明确。招募了一组帕金森病患者和健康对照者，收集他们的临床特征和血浆。进行了基于非靶向液相色谱 - 质谱的血浆代谢组学分析。分别在男性和女性参与者中鉴定出患者与健康对照之间差异表达的代谢物，并进一步进行代谢物集富集分析。共纳入75例帕金森病患者（37例男性和38例女性）和31例健康对照者（16例男性和15例女性），临床特征方面未发现显著差异。通过正交偏最小二乘判别分析构建的男性特异性代谢模型不能很好地识别女性患者，女性特异性模型也不能准确识别男性患者。男性参与者中有55种差异表达的代谢物，脂肪酸及其共轭物和类二十烷酸是显著富集的代谢物集。同时，女性参与者中有86种代谢物差异表达，脂肪酸及其共轭物和甘油磷酸胆碱富集。男性和女性患者中只有17种代谢物同时发生变化。帕金森病患者存在显著的脂质代谢性别差异。
