Wang Wei, Huang Lian, Qiu Xiu Ping, Tu Mei, Guo Xiu Li
Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, Fujian, China.
Sci Rep. 2024 Dec 28;14(1):31396. doi: 10.1038/s41598-024-82994-4.
The monocyte-to-Apolipoprotein A1 ratio (MAR) emerges as a potentially valuable inflammatory biomarker indicative of metabolic dysfunction-associated fatty liver disease (MASLD). Accordingly, this investigation primarily aims to assess the correlation between MAR and MASLD risk. A cohort comprising 957 individuals diagnosed with type 2 diabetes mellitus (T2DM) participated in this study. The relationship between MAR and MASLD was analyzed through binomial logistic regression analysis and restricted cubic splines (RCS). Furthermore, a comparative assessment of MAR and monocyte to high-density lipoprotein ratio (MHR) in identifying MASLD efficacy was conducted using receiver operating characteristic curve analysis. Remarkably, even after adjusting for metabolic parameters and hepatic functional markers, MAR stood out as an independent predictor for MASLD (OR 1.58, 95% CI 1.36-1.84; P < 0.001) and displayed a nonlinear positive association with MASLD risk according to RCS analysis (P for nonlinearity and overall < 0.001). Notably, MAR exhibited superior diagnostic accuracy for identifying MASLD compared to MHR (AUC: 0.772 vs 0.722, P < 0.001). In summary, MAR emerges as a promising inflammatory indicator for MASLD, demonstrating potential as a valuable screening tool to bolster the management of MASLD within the T2DM population.
单核细胞与载脂蛋白A1比值（MAR）已成为一种潜在有价值的炎症生物标志物，可指示代谢功能障碍相关脂肪性肝病（MASLD）。因此，本研究主要旨在评估MAR与MASLD风险之间的相关性。一项队列研究纳入了957名被诊断为2型糖尿病（T2DM）的个体。通过二项逻辑回归分析和限制性立方样条（RCS）分析了MAR与MASLD之间的关系。此外，使用受试者工作特征曲线分析对MAR和单核细胞与高密度脂蛋白比值（MHR）在识别MASLD效能方面进行了比较评估。值得注意的是，即使在调整了代谢参数和肝功能指标后，MAR仍是MASLD的独立预测因子（OR 1.58，95%CI 1.36 - 1.84；P < 0.001），并且根据RCS分析显示与MASLD风险呈非线性正相关（非线性和总体P < 0.001）。值得注意的是，与MHR相比，MAR在识别MASLD方面表现出更高的诊断准确性（AUC：0.772对0.722，P < 0.001）。总之，MAR成为MASLD一种有前景的炎症指标，显示出作为一种有价值的筛查工具的潜力，以加强T2DM人群中MASLD的管理。
