Liu Zhaohui, Wang Xiangyu, Yang Genhua, Li Jiefeng, Lu Yongsheng, Sun Dayong, Wu Ruinuan
Department of Gastroenterology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Marshall Laboratory of Biomedical Engineering, Shenzhen University, Shenzhen, China.
Sci Rep. 2024 Dec 28;14(1):31476. doi: 10.1038/s41598-024-83203-y.
To date, no prospective study has been conducted to compare the safety and effectiveness of endoscopic snare resection with an elastic band (ESR-EB) and endoscopic snare resection with a transparent cap (ESR-C) for treating gastric muscularis propria lesions. We aimed to compare the safety and effectiveness of ESR-EB with those of ESR-C for gastric muscularis propria lesions less than 10 mm in diameter. A total of 64 patients were enrolled prospectively from May 2023 to November 2023 at Shenzhen Hospital of Southern Medical University, the First Affiliated Hospital of Shantou University, and the People's Hospital of Zhongshan City. The study compared clinical characteristics, tumour features, and surgical outcomes between the two groups. Of 64 patients, 29 underwent ESR-C, and 35 underwent ESR-EB. There were no differences in age, gender, location, tumour size, growth pattern, resection time, histology diagnosis, or follow-up time (P > 0.05). Complete resection was achieved in all the patients. The operation time was significantly greater in the ESR-C group than in the ESR-EB group (41.31 ± 9.87 min vs. 26.26 ± 10.32 min, P = 0.000). In the ESR-C cohort, 21 patients (72.41%) had perforation, and 1 patient (3.45%) had bleeding. In the ESR-EB group, 7 patients (20.00%) had perforation. The complication rate varied significantly between the two groups (P = 0.000). No recurrence or metastasis was observed in either group during the follow-up period. Both ESR-C and ESR-EB achieved a 100% complete resection rate for gastric muscularis propria lesions less than 10 mm in diameter.ESR-EB had the potential to reduce the operation time and lower the occurrence of complications. Chinese Clinical Trial Registry Identifier ChiCTR2300072856.
迄今为止，尚未进行前瞻性研究来比较内镜下弹性圈套切除术（ESR-EB）和内镜下透明帽圈套切除术（ESR-C）治疗胃固有肌层病变的安全性和有效性。我们旨在比较ESR-EB与ESR-C治疗直径小于10毫米的胃固有肌层病变的安全性和有效性。2023年5月至2023年11月，南方医科大学深圳医院、汕头大学医学院第一附属医院和中山市人民医院共前瞻性纳入64例患者。该研究比较了两组患者的临床特征、肿瘤特征和手术结果。64例患者中，29例行ESR-C，35例行ESR-EB。两组患者在年龄、性别、病变部位、肿瘤大小、生长方式、切除时间、组织学诊断或随访时间方面均无差异（P＞0.05）。所有患者均实现完全切除。ESR-C组的手术时间显著长于ESR-EB组（41.31±9.87分钟 vs. 26.26±10.32分钟，P = 0.000）。在ESR-C队列中，21例患者（72.41%）发生穿孔，1例患者（3.45%）发生出血。在ESR-EB组中，7例患者（20.00%）发生穿孔。两组的并发症发生率差异显著（P = 0.000）。随访期间两组均未观察到复发或转移。ESR-C和ESR-EB对直径小于10毫米的胃固有肌层病变均实现了100%的完全切除率。ESR-EB有可能缩短手术时间并降低并发症的发生率。中国临床试验注册标识符：ChiCTR2300072856。
