补充条纹鳢提取物对接受化疗的急性髓系白血病患者发热性中性粒细胞减少症的影响：一项随机对照研究。

Effect of Channa striata Extract Supplementation on Febrile Neutropenia in Acute Myeloid Leukemia Patients Undergoing Chemotherapy: A Randomized Controlled Study.

作者信息

Setiawan Budi, Pangarsa Eko Adhi, Santosa Damai, Rizky Daniel, Tandarto Kevin, Suharti Catharina

机构信息

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Semarang, Indonesia.

Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Semarang, Indonesia.

出版信息

Asian Pac J Cancer Prev. 2024 Dec 1;25(12):4265-4271. doi: 10.31557/APJCP.2024.25.12.4265.

DOI:10.31557/APJCP.2024.25.12.4265

PMID:39733418

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12008328/

Abstract

INTRODUCTION

Febrile neutropenia is one of the most serious complications in patients with hematological malignancies and chemotherapy. Channa striata is a freshwater fish belonging to the family Channidae. This study aims to determine whether the administration of channa striata extract can increase neutrophil count, neutrophil function and prevent incidence of febrile neutropenia in acute myeloid leukemia (AML) patients receiving chemotherapy.

METHOD

A randomized, single-blind, controlled study compared a standard nutrition from hospital with a channa striata extract-supplemented per oral containing 6 grams of channa striata extract in patients with acute myeloid leukemia undergoing intensive chemotherapy. To analyze the effects of channa striata extract on function of neutrophil, Interleukin (IL)-6 and nitric oxide (NO) levels which are the result of neutrophil phagocytosis were assessed.

RESULTS

A total of 32 AML patients were randomized to receive per oral supplementation of channa striata extract (6 g/day) or nutrition from the hospital during intensive chemotherapy and after chemotherapy. The median onset of neutropenia was 6.1 + 3.37 in the channa striata extract group and 8.8 + 4.59 in the control group (p=0.109). The median duration of neutropenia was 12.8 + 6.20 d in the channa striata group and 17.2 + 11.06 d in the control group (p=0.281), whereas the incidence of febrile neutropenia were 85,7% in the channa striata extract group and 43,8% in the control group with median duration of neutropenic fever were 5.7 + 3.56 and 4.7 + 4.57, respectively. The chi-square test in the IL-6 delta category showed a tendency for IL-6 levels to rise in 61.5% of subjects in the Channa striata group compared to the control group (p=0.182).

CONCLUSION

Channa striata extract supplementation did not influence neutropenia onset, duration, neutrophil function, or neutropenic fever in AML patients.

摘要

引言

发热性中性粒细胞减少是血液系统恶性肿瘤患者和接受化疗患者最严重的并发症之一。条纹鳢是一种属于鳢科的淡水鱼。本研究旨在确定给予条纹鳢提取物是否能增加急性髓系白血病（AML）化疗患者的中性粒细胞计数、中性粒细胞功能并预防发热性中性粒细胞减少的发生。

方法

一项随机、单盲、对照研究将医院提供的标准营养与口服补充6克条纹鳢提取物的营养对接受强化化疗的急性髓系白血病患者进行了比较。为分析条纹鳢提取物对中性粒细胞功能的影响，评估了作为中性粒细胞吞噬作用结果的白细胞介素（IL）-6和一氧化氮（NO）水平。

结果

共有32例AML患者在强化化疗期间及化疗后被随机分为口服补充条纹鳢提取物（6克/天）组或医院提供的营养组。条纹鳢提取物组中性粒细胞减少的中位发病时间为6.1 + 3.37天，对照组为8.8 + 4.59天（p = 0.109）。条纹鳢组中性粒细胞减少的中位持续时间为12.8 + 6.20天，对照组为17.2 + 11.06天（p = 0.281），而发热性中性粒细胞减少的发生率在条纹鳢提取物组为85.7%，对照组为43.8%，中性粒细胞减少性发热的中位持续时间分别为5.7 + 3.56天和4.7 + 4.57天。IL-6变化类别中的卡方检验显示，与对照组相比，条纹鳢组61.5%的受试者IL-6水平有升高趋势（p = 0.182）。