Daryanti Saragih Ita, Susanto Herry, Lin Hsiao-Ching, Lee Bih-O
College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan.
Faculty of Nursing, Universitas Islam Sultan Agung, Semarang, Indonesia.
J Tissue Viability. 2025 Feb;34(1):100852. doi: 10.1016/j.jtv.2024.100852. Epub 2024 Dec 21.
Hard-to-heal wounds lead to functional loss, decreased quality of life, and prolonged hospitalization due to delayed healing. The healthcare costs of managing such wounds are substantial. Vibration therapy has been proposed as an alternative treatment for hard-to-heal wounds but no comprehensive reviews have quantitatively analyzed its efficacy.
Six databases were systematically searched for relevant articles on August 1, 2024. The methodologies of the studies included in the analysis were assessed using Version 2 of the Cochrane Risk of Bias tool for randomized trials and ROBINS-I tool for non-randomized studies. A random-effects model was applied to aggregate the pooled effect size. Heterogeneity was assessed using I. A forest plot was generated for meta-analysis.
Ten studies were included in the meta-analysis. Vibration therapy significantly reduced neuropathy (pooled standardized mean difference [SMD] = -0.79; 95 % CI = -1.51 to -0.07; p = 0.03; I = 61.40 %) and enhanced the ulcer healing area (pooled SMD = 0.92; 95 % CI = 0.60 to 1.23; p < 0.001; I = 0.00 %) of patients with hard-to-heal wounds. However, the intervention did not significantly alleviate pain (pooled SMD = -0.51; 95 % CI = -1.38 to 0.36; p = 0.25; I = 74.15 %). Significant heterogeneity was identified in the pooled result for pain and neuropathy.
Vibration therapy appears to enhance ulcer healing and reduce neuropathy. These results may help researchers and healthcare providers to further develop vibration therapy to address the underlying requirements for bridging the evidence-practice gap in wound care. Future studies should consider the safety and potential adverse outcomes of vibration therapy to ensure its appropriate application for treating hard-to-heal wounds.
难愈合伤口会导致功能丧失、生活质量下降，且因愈合延迟而延长住院时间。处理此类伤口的医疗费用高昂。振动疗法已被提议作为难愈合伤口的替代治疗方法，但尚无全面综述对其疗效进行定量分析。
于2024年8月1日系统检索六个数据库以获取相关文章。使用Cochrane随机试验偏倚风险工具第2版和非随机研究的ROBINS-I工具评估纳入分析的研究方法。应用随机效应模型汇总合并效应量。使用I²评估异质性。生成森林图进行荟萃分析。
荟萃分析纳入了十项研究。振动疗法显著减轻了难愈合伤口患者的神经病变（合并标准化均数差[SMD]= -0.79；95%置信区间[CI]= -1.51至-0.07；p = 0.03；I² = 61.40%），并增大了溃疡愈合面积（合并SMD = 0.92；95% CI = 0.60至1.23；p < 0.001；I² = 0.00%）。然而，该干预措施并未显著减轻疼痛（合并SMD = -0.51；95% CI = -1.38至0.36；p = 0.25；I² = 74.15%）。在疼痛和神经病变的合并结果中发现了显著异质性。
振动疗法似乎能促进溃疡愈合并减轻神经病变。这些结果可能有助于研究人员和医疗服务提供者进一步开发振动疗法，以满足弥合伤口护理证据与实践差距的潜在需求。未来的研究应考虑振动疗法的安全性和潜在不良后果，以确保其在治疗难愈合伤口方面的恰当应用。
