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医生对颈动脉血运重建的偏好会影响术后中风和死亡结局。

Physicians' preference for carotid revascularization impacts postoperative stroke and death outcomes.

作者信息

Aridi Hanaa D, Frank Geneva, Gutwein Ashley R, Madison Mackenzie, Schermerhorn Marc L, Kashyap Vikram S, Wang Grace, Eldrup-Jorgensen Jens, Malas Mahmoud, Motaganahalli Raghu

机构信息

Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN.

Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis, IN.

出版信息

J Vasc Surg. 2025 May;81(5):1092-1103.e2. doi: 10.1016/j.jvs.2024.12.125. Epub 2024 Dec 27.

Abstract

OBJECTIVE

Transcarotid artery revascularization (TCAR) is a safe minimally invasive option for patients with carotid artery stenosis who are not appropriate candidates for carotid endarterectomy (CEA). Many physicians have not yet adopted this technique in the management of carotid artery stenosis. The aim of this study is to explore overall outcomes of carotid revascularization based on physicians' practices in the Vascular Quality Initiative (VQI).

METHODS

Individual physicians participating in both the carotid artery stenting (CAS) and carotid endarterectomy (CEA) modules in VQI were categorized as performing CEA and TCAR, CEA and transfemoral carotid artery stenting (TFCAS), or all three procedures (CEA, TCAR, and TFCAS). Physicians performing CEA only or TCAR/TFCAS only were excluded. In-hospital and 1-year outcomes were compared between the three groups using univariable and multivariable analysis.

RESULTS

A total of 104,925 carotid revascularization procedures performed by 1433 physicians were included. Most physicians performed CEA and TCAR (n = 714; 49.8%), whereas 35.1% (n = 503) performed all three procedures, and 15.1% (n = 216) performed CEA and TFCAS only. Physicians performing CEA and TFCAS had higher overall stroke/death rates after carotid procedures (2.2%) compared with those performing CEA and TCAR (1.4%) or those performing all three procedures (1.6%; P < .001). They also had higher rates of cranial nerve injuries (3.1% vs 1.9% vs 1.9%; P < .001). After adjusting for baseline characteristics, procedures performed by CEA and TFCAS physicians had significantly higher odds of in-hospital stroke/death compared with those in the CEA and TCAR group (odds ratio, 1.31; 95% confidence interval [CI], 1.03-1.66; P = .03). They also had increased hazard of 1-year stroke/death (hazard ratio, 1.45; 95% CI, 1.1-1.9; P = .01). No significant difference in the adjusted odds of stroke/death was observed between CEA and TCAR performers vs CEA, TCAR, and TFCAS performers (odds ratio, 1.05; 95% CI, 0.92-1.20; P = .44). When adjusting for the type of carotid revascularization technique, difference in outcomes based on surgeon's experience were no longer significant, indicating that differences in outcomes were procedure-specific and attributable to the inferior outcomes associated with TFCAS compared with CEA and TCAR. TCAR case volumes did not impact outcomes of carotid revascularization. On the other hand, a high TFCAS volume among physicians performing all three carotid procedures was associated with higher overall in-hospital and 1-year mortality.

CONCLUSIONS

Physicians' preference for carotid artery stenosis management has a bearing on their overall stroke/death rates. Careful patient and procedure selection are the cornerstone to improve carotid revascularization outcomes.

摘要

目的

经颈动脉血管重建术(TCAR)对于那些不适合接受颈动脉内膜切除术(CEA)的颈动脉狭窄患者而言,是一种安全的微创选择。许多医生尚未在颈动脉狭窄的治疗中采用这项技术。本研究的目的是基于血管质量倡议(VQI)中医生的实践情况,探讨颈动脉血管重建术的总体结果。

方法

参与VQI中颈动脉支架置入术(CAS)和颈动脉内膜切除术(CEA)模块的个体医生被分类为进行CEA和TCAR、CEA和经股颈动脉支架置入术(TFCAS)或所有三种手术(CEA、TCAR和TFCAS)。仅进行CEA或仅进行TCAR/TFCAS的医生被排除。使用单变量和多变量分析比较三组的住院期间和1年的结果。

结果

共纳入了1433名医生进行的104,925例颈动脉血管重建手术。大多数医生进行CEA和TCAR(n = 714;49.8%),而35.1%(n = 503)进行所有三种手术,15.1%(n = 216)仅进行CEA和TFCAS。与进行CEA和TCAR的医生(1.4%)或进行所有三种手术的医生(1.6%;P <.001)相比,进行CEA和TFCAS的医生在颈动脉手术后的总体卒中/死亡率更高(2.2%)。他们的颅神经损伤发生率也更高(3.1%对1.9%对1.9%;P <.001)。在对基线特征进行调整后,与CEA和TCAR组相比,CEA和TFCAS医生进行的手术在住院期间发生卒中/死亡的几率显著更高(优势比,1.31;95%置信区间[CI]为1.03 - 1.66;P =.03)。他们1年卒中/死亡的风险也增加了(风险比,1.45;95%CI为1.1 - 1.9;P =.01)。在CEA和TCAR手术医生与CEA、TCAR和TFCAS手术医生之间,调整后的卒中/死亡几率没有显著差异(优势比,1.05;95%CI为0.92 - 1.20;P =.44)。在调整颈动脉血管重建技术类型后,基于外科医生经验的结果差异不再显著,这表明结果差异是特定于手术的,并且归因于与CEA和TCAR相比,TFCAS的结果较差。TCAR的病例数量并未影响颈动脉血管重建的结果。另一方面,在进行所有三种颈动脉手术的医生中,高TFCAS数量与更高的总体住院期间和1年死亡率相关。

结论

医生对颈动脉狭窄治疗的偏好对其总体卒中/死亡率有影响。仔细的患者和手术选择是改善颈动脉血管重建结果的基石。

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