Heinen G D, Garzón A G, Cian R E, Drago S R
Instituto de Tecnología de Alimentos, CONICET, FIQ - UNL, 1° de Mayo 3250, 3000 Santa Fe, Argentina.
Instituto de Tecnología de Alimentos, CONICET, FIQ - UNL, 1° de Mayo 3250, 3000 Santa Fe, Argentina.
Int J Biol Macromol. 2025 Mar;292:139237. doi: 10.1016/j.ijbiomac.2024.139237. Epub 2024 Dec 27.
Three microcapsule formulations with 2.7, 5.5 and 10.9 g calcium 100 g solids (C1, C2, and C3, respectively) were developed using brewer spent grain arabinoxylan concentrate as wall material. The intestinal and colonic bioaccessibility of calcium and phenolic compounds were determined after in vitro gastrointestinal digestion. The level of calcium and the formation of Ca:AX complexes mediated by electrostatic interactions contributed to the construction of the microcapsule wall. It was observed that the higher calcium content increased the total calcium bioaccessibility (27.0 ± 2.4, 29.8 ± 0.2, 37.1 ± 1.0 % for C1, C2, and C3, respectively). However, the calcium level of the microcapsules decreased the total bioaccessibility of the phenolic compounds from 45 to 27 % for ferulic acid, and from 90 to 66 % for p-coumaric acid for C1 and C3, respectively. Also, the secondary metabolites of these phenolics were detected in the colonic fractions. Suitable microcapsules intendant for the supplementation of people with a calcium deficient diet, with the supply of fermentable fibres and phenolic compounds were developed.
以啤酒糟阿拉伯木聚糖浓缩物为壁材，制备了三种钙含量分别为2.7、5.5和10.9 g/100 g固体的微胶囊制剂（分别为C1、C2和C3）。体外胃肠道消化后，测定了钙和酚类化合物的肠道和结肠生物可及性。钙的含量以及由静电相互作用介导的Ca:AX复合物的形成有助于微胶囊壁的构建。观察到较高的钙含量提高了总钙生物可及性（C1、C2和C3分别为27.0±2.4%、29.8±0.2%和37.1±1.0%）。然而，微胶囊中的钙含量分别使阿魏酸的酚类化合物总生物可及性从45%降至27%，对香豆酸的总生物可及性从90%降至66%（分别针对C1和C3）。此外，在结肠部分检测到了这些酚类物质的次级代谢产物。开发了适合为缺钙饮食人群补充钙、可提供可发酵纤维和酚类化合物的微胶囊。
