双重打击：一例接受纳武单抗治疗患者出现免疫检查点抑制剂相关性结肠炎合并并存性结肠炎的病例报告
Double Whammy: A Case Report of Immune Checkpoint Inhibitor Colitis and Concomitant Colitis in a Patient on Nivolumab.
作者信息
Gautam Misha, Jahagirdar Vinay, Mahadevia Himil, Sanders Kimberly, Campbell John P, Sylvestre Pamela B, Chhabra Rajiv, Clarkston Wendell, Jonnalagadda Sreenivasa S
机构信息
Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO.
Gastroenterology and Hepatology, University of Missouri-Kansas City School of Medicine, Kansas City, MO.
出版信息
ACG Case Rep J. 2024 Dec 27;12(1):e01569. doi: 10.14309/crj.0000000000001569. eCollection 2025 Jan.
Immune checkpoint inhibitors commonly cause gastrointestinal immune-related adverse effects. These patients also carry an increased risk of concomitant infections. This 66-year-old man with immune checkpoint inhibitor colitis was discovered to have concurrent and colitis. Such infections may mimic or complicate disease course. Hence, clinicians must monitor patient symptoms, have a low threshold for infectious testing and colonoscopy, and consider treatment strategies to mitigate their risk.
免疫检查点抑制剂通常会引起胃肠道免疫相关不良反应。这些患者同时发生感染的风险也会增加。这位66岁患有免疫检查点抑制剂相关性结肠炎的男性被发现同时患有[此处原文缺失具体感染类型]感染和结肠炎。此类感染可能会模仿疾病病程或使病程复杂化。因此，临床医生必须监测患者症状，对进行感染检测和结肠镜检查保持较低的阈值，并考虑采取治疗策略以降低风险。
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