Cao Shuzhu, Xie Songsong, Song Shengnan, Gu Xiu, Sun Zhihua, Deng Xingmei, Guo Jia, Zhao Tianyi, Chai Yingjin, Zhu Dexin, Liu Xiafei, Wu Xiangwei, Zhang Hui
State International Joint Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, People's Republic of China.
NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital of Shihezi University, Xinjiang, People's Republic of China.
Infect Drug Resist. 2024 Dec 25;17:5847-5853. doi: 10.2147/IDR.S493174. eCollection 2024.
Brucellosis, a major endemic disease in northern China, is contracted by zoonosis of . We report a case of meningitis caused by biovar 3.
A 46-year-old man was hospitalized at a local medical facility due to symptoms of fever, soreness, and weakness on April 16, 2021. The local hospital improved the relevant examinations, and the serum tube agglutination test (SAT) for was positive. The patient underwent a week of anti-infective symptomatic treatment with doxycycline and rifampicin, however, his symptoms continued. Subsequently, he was hospitalized in our facility following convulsions and altered consciousness. We conducted several examinations, and the lumbar puncture revealed abnormal cerebrospinal fluid (CSF) protein levels along with a positive culture. Biochemical and polymerase chain reaction (PCR) tests (based on gene) identified the pathogen as biovar 3. Following treatment involving with moxifloxacin hydrochloride, doxycycline, rifampin, cefatriaxone, mannitol, and dexamethasone the patient's body temperature stabilized, leading to gradual improvements in his clinical status. After two months of the oral anti-infective regimen, the condition is continuing to alleviate and the laboratory indicators returned to normal. The follow-up maintained two years, the patient with no symptomatic recurrences or sequel.
We showed that in epidemic areas of brucellosis, patients with unexplained neurological symptoms should first be examined for neurobrucellosis. Early treatment with corticosteroids and a combination of antibiotics is beneficial for the relief and satisfactory prognosis of neurological symptoms.
布鲁氏菌病是中国北方一种主要的地方病，通过动物传染给人。我们报告一例由生物变种3引起的脑膜炎病例。
一名46岁男性于2021年4月16日因发热、酸痛和虚弱症状入住当地医疗机构。当地医院完善了相关检查，布鲁氏菌血清试管凝集试验（SAT）呈阳性。患者接受了为期一周的强力霉素和利福平抗感染对症治疗，但症状持续。随后，他在抽搐和意识改变后入住我院。我们进行了多项检查，腰椎穿刺显示脑脊液（CSF）蛋白水平异常且培养阳性。生化和聚合酶链反应（PCR）检测（基于布鲁氏菌基因）确定病原体为生物变种3。经过盐酸莫西沙星、强力霉素、利福平、头孢曲松、甘露醇和地塞米松治疗，患者体温稳定，临床状况逐渐改善。经过两个月的口服抗感染治疗，病情持续缓解，实验室指标恢复正常。随访两年，患者无症状复发或后遗症。
我们表明，在布鲁氏菌病流行地区，有不明原因神经症状的患者应首先检查是否患有神经型布鲁氏菌病。早期使用皮质类固醇和联合抗生素治疗有利于缓解神经症状并获得满意的预后。
