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巴勒斯坦公共卫生诊所2型糖尿病管理中对美国糖尿病协会临床指南的遵循情况。

Adherence to ADA Clinical Guidelines in Type 2 Diabetes Management in Public Health Clinics in Palestine.

作者信息

Abukhalil Abdallah Damin, Muhanna Sana Ali, Madi Misk Najih, Al-Shami Ni'meh, Naseef Hani A, Rabba Abdullah K

机构信息

Department of Pharmacy, Faculty of Pharmacy, Nursing, and Health Professions, Birzeit University, Birzeit, Palestine.

出版信息

Patient Prefer Adherence. 2024 Dec 25;18:2667-2680. doi: 10.2147/PPA.S494951. eCollection 2024.

Abstract

BACKGROUND

The prevalence of type 2 diabetes is a significant global public health concern. Adherence to established guidelines is essential for effective management of this metabolic disease.

OBJECTIVE

This study aimed to evaluate the current practices of physicians in Palestine regarding their adherence to ADA guidelines for type 2 diabetes management.

METHODS

A retrospective, cross-sectional, multicenter study was conducted by reviewing patients' medical records. This study included 362 patients aged ≥ 18 years diagnosed with type 2 diabetes for at least one year and receiving treatment at multiple outpatient clinics in Palestine. Adherence to ADA guidelines was assessed by selecting an appropriate antidiabetic agent based on patient confounding factors and comorbidities, frequency of diabetes monitoring, screening, glycemic control, and optimization of hypertension and dyslipidemia medication.

RESULTS

Half of the participants were female. 53% of the participants did not achieve their A1c target goal. Adherence to ADA guidelines for selecting the preferred antidiabetic medication was only 32.22%. Very low adherence to prescribing GLP1 agonists (0.5%) and SGLT2 inhibitors (7%) when indicated. Biguanides were the most prescribed medications (83.1%), followed by sulfonylurea (35.1%), and insulin (28.2%). Only 43% and 66% of the patients were on appropriate lipid and hypertension medications, respectively, as recommended by ADA guidelines. Foot assessment and eye examinations were performed in only 27% and 55% of the patients, respectively. Age, atherosclerotic cardiovascular disease, and sulfonylurea use were significantly associated with lower glycemic control.

CONCLUSION

This study demonstrated that Adherence to ADA guidelines for diabetes management is suboptimal in selecting appropriate antidiabetic medication based on patient confounding factors, potentially contributing to the high prevalence of complications and comorbidities observed in patients with diabetes in Palestine. Medical associations and health institutions must adopt programs to increase professional education and awareness of the current guidelines to improve outcomes.

摘要

背景

2型糖尿病的患病率是一个重大的全球公共卫生问题。遵循既定指南对于有效管理这种代谢性疾病至关重要。

目的

本研究旨在评估巴勒斯坦医生在遵循美国糖尿病协会(ADA)2型糖尿病管理指南方面的当前做法。

方法

通过回顾患者的病历进行了一项回顾性、横断面、多中心研究。本研究纳入了362名年龄≥18岁、被诊断为2型糖尿病至少一年且在巴勒斯坦多个门诊接受治疗的患者。根据患者的混杂因素和合并症选择合适的抗糖尿病药物、糖尿病监测频率、筛查、血糖控制以及高血压和血脂异常药物的优化情况来评估对ADA指南的遵循情况。

结果

一半的参与者为女性。53%的参与者未达到糖化血红蛋白(A1c)目标值。在选择首选抗糖尿病药物方面对ADA指南的遵循率仅为32.22%。在有指征时,对开具胰高血糖素样肽-1(GLP1)激动剂(0.5%)和钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂(7%)的遵循率非常低。双胍类药物是最常开具的药物(83.1%),其次是磺脲类药物(35.1%)和胰岛素(28.2%)。分别只有43%和66%的患者按照ADA指南的建议使用了合适的降脂和降压药物。仅分别有27%和55%的患者进行了足部评估和眼部检查。年龄、动脉粥样硬化性心血管疾病和使用磺脲类药物与血糖控制较差显著相关。

结论

本研究表明,在根据患者混杂因素选择合适的抗糖尿病药物方面,对ADA糖尿病管理指南的遵循情况欠佳,这可能是导致巴勒斯坦糖尿病患者并发症和合并症高发的原因之一。医学协会和卫生机构必须采取措施加强专业教育并提高对当前指南的认识,以改善治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa08/11682676/6eb9ca7e410e/PPA-18-2667-g0001.jpg

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