Dey Subir, Debanath Abhinav
Commanding Officer, 302 Field Hospital, C/o 99 APO, India.
SSMO Neurosurgery, YCM Hospital & PGI, Pimpri, Pune, India.
Med J Armed Forces India. 2024 Dec;80(Suppl 1):S264-S267. doi: 10.1016/j.mjafi.2023.01.005. Epub 2023 Mar 9.
Intracranial epidermoid cyst (EC) is a slow-growing, benign lesion that rarely undergoes a malignant transformation. When it does occur, the clinical course is aggressive. Certain radiological criteria may give a clue to diagnosis and help in deciding the appropriate course of action as well as prognostication. Surgical excision along with adjuvant radiotherapy is the treatment of choice; however, the overall prognosis is poor as complete excision is seldom possible. We present a rare case of malignant transformation of an intracranial EC without previous history of surgery. Subtotal excision of the lesion was possible, with post-operative histopathological examination revealing squamous cell carcinoma. The patient was discharged from the hospital with no fresh deficits. She was, however, re-admitted on day 36 with features of raised intracranial pressure, for which she underwent cerebrospinal fluid diversion. She underwent intensity-modulated radiation therapy later on.
颅内表皮样囊肿（EC）是一种生长缓慢的良性病变，很少发生恶变。一旦发生恶变，临床病程进展迅速。某些影像学标准可能有助于诊断，并有助于确定适当的治疗方案和预后。手术切除联合辅助放疗是首选治疗方法；然而，由于很少能做到完全切除，总体预后较差。我们报告一例罕见的颅内EC恶变病例，此前无手术史。该病变可行次全切除，术后组织病理学检查显示为鳞状细胞癌。患者出院时无新的神经功能缺损。然而，她在第36天因颅内压升高再次入院，为此接受了脑脊液分流术。她随后接受了调强放射治疗。
