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多西他赛诱导的肺损伤。

Docetaxel-induced lung injury.

作者信息

Vasan Amit Singh, Chowdhary Gurjeet Singh, Pandey Indramani, Garg Yadvir, Soneji Dharmesh

机构信息

Graded Specialist (Pulmonary Medicine), Command Hospital (Western Command), Chandimandir, Haryana, India.

Senior Advisor (Medical Oncology), Command Hospital (Western Command), Chandimandir, Haryana, India.

出版信息

Med J Armed Forces India. 2024 Dec;80(Suppl 1):S275-S278. doi: 10.1016/j.mjafi.2023.02.002. Epub 2023 Apr 10.

Abstract

Docetaxel is a chemotherapeutic agent commonly used against breast cancer, nonsmall cell lung cancer, gastric, prostate, head and neck cancer. Docetaxel- or taxane-induced interstitial lung disease (ILD) remains a relatively rare reported adverse event. Although rare, this complication remains an important event to identify and it carries a high mortality. We reported the case series of three patients who had pulmonary toxicity after docetaxel administration. Although literature has described patients progressing to respiratory failure and intubation, our patients responded well to steroid treatment and discontinued docetaxel administration.

摘要

多西他赛是一种常用于治疗乳腺癌、非小细胞肺癌、胃癌、前列腺癌、头颈癌的化疗药物。多西他赛或紫杉烷诱导的间质性肺病(ILD)仍然是一种报道相对较少的不良事件。尽管罕见,但这种并发症仍然是一个需要识别的重要事件,并且具有很高的死亡率。我们报告了3例多西他赛给药后出现肺部毒性的病例系列。虽然文献中描述了患者进展为呼吸衰竭和插管,但我们的患者对类固醇治疗反应良好,并停止了多西他赛给药。

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Docetaxel-induced lung injury.多西他赛诱导的肺损伤。
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本文引用的文献

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Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer.
Semin Oncol. 2001 Aug;28(4 Suppl 15):3-7. doi: 10.1016/s0093-7754(01)90148-4.
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Paclitaxel-induced acute bilateral pneumonitis.紫杉醇诱导的急性双侧肺炎。
Ann Pharmacother. 1997 Dec;31(12):1471-4. doi: 10.1177/106002809703101205.
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Docetaxel.多西他赛
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