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氟哌啶醇诱发的喉肌张力障碍:一例抗精神病药物相关气道急症的病例报告。

Haloperidol-Induced Laryngeal Dystonia: A Case Report on an Antipsychotic-Associated Airway Emergency.

作者信息

Guani Lorenzo E, Arshoun Angelica, Murdock Andrew S, Espiridion Eduardo D

机构信息

Psychiatry, Drexel University College of Medicine, West Reading, USA.

Psychiatry, Reading Hospital - Tower Health, West Reading, USA.

出版信息

Cureus. 2024 Nov 29;16(11):e74761. doi: 10.7759/cureus.74761. eCollection 2024 Nov.

Abstract

Acute dystonia is a neurological condition characterized by involuntary muscle contractions that can affect various parts of the body. It is commonly triggered by the use of antipsychotic medications, especially within the first few days after administration. Respiratory acute laryngeal dystonia, a particularly severe form of this condition and a very subtype of laryngeal dystonia, can lead to respiratory distress and airway obstruction if not promptly treated. This case report describes a 23-year-old male who developed acute laryngeal dystonia within 24 hours of receiving haloperidol for agitation. The patient presented with hoarseness, difficulty swallowing, and progressive respiratory distress, eventually requiring emergent intubation due to airway compromise. This case underscores the need for healthcare providers to recognize and promptly manage rare but potentially life-threatening side effects of antipsychotic medications. Particular attention must be directed toward patients with risk factors for developing extrapyramidal reactions. Early intervention is crucial to prevent progression to airway obstruction and respiratory failure.

摘要

急性肌张力障碍是一种神经系统疾病,其特征为不自主的肌肉收缩,可影响身体的各个部位。它通常由使用抗精神病药物引发,尤其是在用药后的头几天内。呼吸性急性喉肌张力障碍是这种疾病的一种特别严重的形式,也是喉肌张力障碍的一个非常特殊的亚型,如果不及时治疗,可导致呼吸窘迫和气道阻塞。本病例报告描述了一名23岁男性,在接受氟哌啶醇治疗躁动后24小时内发生急性喉肌张力障碍。患者出现声音嘶哑、吞咽困难和进行性呼吸窘迫,最终因气道受损而需要紧急插管。本病例强调了医疗保健提供者认识并及时处理抗精神病药物罕见但可能危及生命的副作用的必要性。必须特别关注有发生锥体外系反应风险因素的患者。早期干预对于防止进展为气道阻塞和呼吸衰竭至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b55e/11682720/d18f067a43d6/cureus-0016-00000074761-i01.jpg

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