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外用糖皮质激素致面部损伤患者的临床及皮肤镜评估

Clinical and Dermoscopic Evaluation of Patients With Topical Steroid Damaged Faces (TSDF).

作者信息

Goel Arushi, Mahendra Aneet, Gupta Sanjeev

机构信息

Dermatology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, IND.

出版信息

Cureus. 2024 Nov 27;16(11):e74624. doi: 10.7759/cureus.74624. eCollection 2024 Nov.

Abstract

Background Topical steroid-dependent or damaged face (TSDF) is a common condition where the widespread availability of over-the-counter topical corticosteroid (TCS)-containing products leads to their misuse and addiction. Prolonged use of these steroids on the face can result in significant side effects. Early diagnosis and cessation of steroid use are important. Dermoscopy can serve as an easy-to-use and non-invasive tool for the early diagnosis and for assessing the exact extent of damage caused by steroid misuse. Aims and objectives To observe the various clinical and demographic features of patients with TSDF, the dermoscopic features of these patients, and to find their association with the potency and duration of application of TCS. Material and methods In this observational, cross-sectional study of 250 patients (aged 12-60 years, both genders) presenting with facial dermatosis and clinical signs of TSDF, having a history of at least one month of TCS use, were enrolled using consecutive sampling. Demographic data, clinical features, and dermoscopic findings were recorded. Dermoscopic results were compared with clinical examination, TCS potency, and duration of application. Results The majority (208; 83.2%) of the patients were females, and most of them belonged to the age group of 26-35 years (87; 34.8%). Hyperpigmentation (101; 40.4%) was the most prevalent indication for TCS use in the study. The most common clinical findings included erythema, hypertrichosis, and telangiectasia. Dermoscopic findings such as linear, serpentine, polygonal, and Y-shaped vessels, along with breaking of the pseudo reticular network, red diffuse areas, Demodex tails, and comedones were significantly associated with the duration of TCS use. Linear vessels, Demodex tails, and comedones also correlated significantly with TCS potency, while most other findings did not. Conclusion Dermoscopy is a novel, non-invasive diagnostic technique for the early identification of TCS abuse. In TSDF, it confirms the diagnosis and predicts disease severity earlier than examination by the naked eye alone.

摘要

背景 面部糖皮质激素依赖或受损(TSDF)是一种常见病症,含外用糖皮质激素(TCS)产品在非处方药中广泛可得,导致其被滥用和成瘾。长期在面部使用这些类固醇会导致严重的副作用。早期诊断和停用类固醇很重要。皮肤镜可作为一种易于使用的非侵入性工具,用于早期诊断和评估类固醇滥用造成的损伤的确切程度。

目的 观察TSDF患者的各种临床和人口统计学特征、这些患者的皮肤镜特征,并找出它们与TCS效力及使用持续时间的关联。

材料与方法 在这项观察性横断面研究中,采用连续抽样法纳入了250例(年龄12 - 60岁,男女皆有)有面部皮肤病和TSDF临床体征、且有至少1个月TCS使用史的患者。记录人口统计学数据、临床特征和皮肤镜检查结果。将皮肤镜检查结果与临床检查、TCS效力及使用持续时间进行比较。

结果 大多数(208例;83.2%)患者为女性,其中大多数属于26 - 35岁年龄组(87例;34.8%)。色素沉着(101例;40.4%)是本研究中使用TCS最常见的指征。最常见的临床发现包括红斑、多毛症和毛细血管扩张。皮肤镜检查发现,如线性、蛇形、多边形和Y形血管,以及假网状网络的断裂、红色弥漫区域、蠕形螨尾和粉刺与TCS使用持续时间显著相关。线性血管、蠕形螨尾和粉刺也与TCS效力显著相关,而大多数其他发现则不然。

结论 皮肤镜是一种用于早期识别TCS滥用的新型非侵入性诊断技术。在TSDF中,它比单纯肉眼检查能更早地确诊并预测疾病严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb6/11680711/e76442423307/cureus-0016-00000074624-i01.jpg

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