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对印度北部一家三级护理中心收治的外用糖皮质激素致面部损伤/依赖(TSDF)患者的描述性研究。

A Descriptive Study of Patients Presenting With Topical Steroid Damaged/Dependent Face (TSDF) to a Tertiary Care Center in Northern India.

作者信息

Sharma Satyendra K, Meher Snigdha, Das Nikhil Ranjan, Dash Siddhartha

机构信息

Dermatology, Venereology and Leprosy, Hind Institute of Medical Sciences, Sitapur, IND.

Dermatology, Hind Institute of Medical Sciences, Sitapur, IND.

出版信息

Cureus. 2024 Dec 11;16(12):e75566. doi: 10.7759/cureus.75566. eCollection 2024 Dec.

Abstract

Introduction Topical steroid damaged/dependent face (TSDF) is defined as the semi-permanent or permanent damage to the skin of the face precipitated by the irrational, indiscriminate, or prolonged use of topical corticosteroids (TCs), resulting in various cutaneous signs and symptoms and psychological dependence on the drug. The objective was to determine the clinical spectrum of TSDF. Methods This was an observational cross-sectional study conducted between May 2021 and April 2022, comprising 100 consecutive patients of TC-induced facial dermatoses who visited the skin and venereal disease OPD of a tertiary care hospital in northern India. Any case with a negative history of TC abuse was excluded from the study. Result The study included 100 subjects of TSDF. Females outnumbered males and the age of the patients ranged from 12 to 55 years with a mean age of 27.6 ± 10.07 years. The majority of patients used TCs on the face for pre-existing acne (41%), followed by melasma (20%). Over-the-counter (63%) was the most common method of acquiring TCs, followed by prescriptions from non-qualified persons (17%) and those provided by friends and relatives (9%). Mometasone (41%) was found to be the most commonly misused TC, followed by clobetasol (31%), and betamethasone (29%). The most common morphological presentation was erythema (42%), followed by acneiform eruptions (22%), steroid-induced rosacea (21%), hyperpigmentation (20%), hypertrichosis (5%) and perioral dermatitis (3%). Conclusion This study highlights the impact of misuse of TCs on the face in a single-center setting and provides a detailed description of the associated factors. Such studies could play a crucial role in addressing this issue. Moreover, strict enforcement of regulations on pharmaceutical companies and non-qualified individuals prescribing TCs could help in decreasing this growing health hazard.

摘要

引言 外用糖皮质激素所致面部损伤/依赖(TSDF)被定义为因不合理、无差别或长期使用外用糖皮质激素(TCs)而导致的面部皮肤半永久性或永久性损伤,会引发各种皮肤体征和症状以及对该药物的心理依赖。目的是确定TSDF的临床谱。方法 这是一项于2021年5月至2022年4月进行的观察性横断面研究,纳入了100例连续就诊于印度北部一家三级医院皮肤性病门诊的TC诱发面部皮肤病患者。任何有TC滥用阴性史的病例均被排除在研究之外。结果 该研究纳入了100例TSDF患者。女性多于男性,患者年龄在12至55岁之间,平均年龄为27.6±10.07岁。大多数患者将TCs用于面部已有的痤疮(41%),其次是黄褐斑(20%)。非处方获取(63%)是获取TCs最常见的方式,其次是来自非专业人员的处方(17%)以及朋友和亲戚提供的药物(9%)。发现莫米松(41%)是最常被滥用的TC,其次是氯倍他索(31%)和倍他米松(29%)。最常见的形态学表现是红斑(42%),其次是痤疮样皮疹(22%)、激素性酒渣鼻(21%)、色素沉着(20%)、多毛症(5%)和口周皮炎(3%)。结论 本研究突出了在单中心环境下滥用TCs对面部的影响,并提供了相关因素的详细描述。此类研究在解决这一问题方面可能发挥关键作用。此外,严格执行针对制药公司和开具TCs的非专业人员的法规,有助于减少这种日益严重的健康危害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d828/11723967/16c6f133886e/cureus-0016-00000075566-i01.jpg

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