Munoli Ashish S, Mantur Prakash G, Jalawadi Vishwanath Malkappa
Internal Medicine, Shri. B. M. Patil Medical College Hospital and Research Centre, Vijayapura, IND.
Medicine, Shri. B. M. Patil Medical College Hospital and Research Centre, Vijayapura, IND.
Cureus. 2024 Nov 29;16(11):e74738. doi: 10.7759/cureus.74738. eCollection 2024 Nov.
This study investigates the relationship between vitamin D levels and liver cirrhosis severity, a leading cause of global morbidity and mortality. Chronic liver diseases, stemming from conditions such as hepatitis, alcohol use, non-alcoholic fatty liver disease, autoimmune diseases, and cryptogenic disorders, disrupt vitamin D metabolism, as the liver converts dietary and skin-derived vitamin D into 25-hydroxyvitamin D (25[OH]D), the primary circulating form. The cross-sectional study conducted at the Department of General Medicine of BLDE (DU) Shri. B. M. Patil Medical College Hospital and Research Centre, Vijayapura, from August 2022 to May 2024, involved 89 patients. Based on the Child-Pugh scoring system, these patients were classified into three classes: class A (good hepatic function), class B (moderate dysfunction), and class C (advanced dysfunction). The study found a significant negative correlation (Pearson r=-0.462, p<0.0001) between vitamin D levels and Child-Pugh scores, indicating that as cirrhosis severity worsens, vitamin D levels decrease. The findings highlight vitamin D deficiency as a marker of disease severity, linking it to increased morbidity and mortality and underscoring its potential as a prognostic tool in managing liver cirrhosis.
本研究调查了维生素D水平与肝硬化严重程度之间的关系，肝硬化是全球发病和死亡的主要原因。慢性肝病源于肝炎、酒精使用、非酒精性脂肪性肝病、自身免疫性疾病和隐源性疾病等，会扰乱维生素D代谢，因为肝脏会将饮食和皮肤来源的维生素D转化为25-羟基维生素D（25[OH]D），这是主要的循环形式。2022年8月至2024年5月在维贾亚普拉的BLDE（DU）什里·B·M·帕蒂尔医学院医院和研究中心普通内科进行的横断面研究涉及89名患者。根据Child-Pugh评分系统，这些患者被分为三类：A类（肝功能良好）、B类（中度功能障碍）和C类（重度功能障碍）。研究发现维生素D水平与Child-Pugh评分之间存在显著负相关（Pearson r=-0.462，p<0.0001），表明随着肝硬化严重程度的加重，维生素D水平会降低。这些发现突出了维生素D缺乏作为疾病严重程度的一个指标，将其与发病率和死亡率的增加联系起来，并强调了其作为肝硬化管理中预后工具的潜力。
