Decuypere E, Kühn E R
J Endocrinol. 1985 Mar;104(3):363-6. doi: 10.1677/joe.0.1040363.
The influence of an intravenous injection of ovine prolactin on the liver monodeiodinase activity and serum concentrations of thyroid hormones and corticosterone was studied in Hisex embryos and chicks after hatching. An injection of 1 and 10 micrograms ovine prolactin into 18-day-old chick embryos increased serum concentrations of tri-iodothyronine (T3) five- and eightfold respectively after 2 h. At the same time serum concentrations of thyroxine (T4) and reverse T3 (rT3) were decreased in the chick embryo, but only with 10 micrograms prolactin. This was accompanied by a doubling of the liver monodeiodinase activity. Serum concentrations of corticosterone, however, were not influenced by the prolactin injections. In the 5-day-old chicken, serum concentrations of T3, rT3, T4 and liver T4-5'-monodeiodinase activity were not influenced by 1 or 10 micrograms prolactin. Serum concentrations of corticosterone after injection of 1 or 10 micrograms prolactin were doubled compared with controls. These results are compatible with a prolactin-induced shift from a T4-5-monodeiodination into a T4-5'-monodeiodination in the liver at the end of incubation. This effect, however, is not mediated through a prolactin-induced corticosterone release.
研究了静脉注射绵羊催乳素对海塞克斯胚胎及出壳后雏鸡肝脏单碘甲腺原氨酸酶活性、甲状腺激素血清浓度和皮质酮的影响。给18日龄鸡胚注射1微克和10微克绵羊催乳素后，2小时后血清三碘甲状腺原氨酸（T3）浓度分别增加了5倍和8倍。与此同时，鸡胚血清甲状腺素（T4）和反式T3（rT3）浓度降低，但仅在注射10微克催乳素时出现这种情况。这伴随着肝脏单碘甲腺原氨酸酶活性加倍。然而，皮质酮的血清浓度不受催乳素注射的影响。在5日龄雏鸡中，1微克或10微克催乳素对T3、rT3、T4的血清浓度和肝脏T4-5'-单碘甲腺原氨酸酶活性没有影响。注射1微克或10微克催乳素后，皮质酮的血清浓度与对照组相比增加了一倍。这些结果与孵化末期催乳素诱导肝脏中从T4-5-单碘甲腺原氨酸化向T4-5'-单碘甲腺原氨酸化的转变相一致。然而，这种作用不是通过催乳素诱导的皮质酮释放介导的。
