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接触式激光汽化术(CVP)治疗有出血风险的良性前列腺增生患者的初步经验

Initial Experience of Contact Laser Vaporization of the Prostate (CVP) for Benign Prostate Hyperplasia Patients With Hemorrhagic Risk.

作者信息

Araki Yushi, Kawahara Takashi, Takeshima Teppei, Makiyama Kazuhide, Uemura Hiroji

机构信息

Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.

Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

出版信息

Adv Urol. 2024 Dec 19;2024:6108816. doi: 10.1155/aiu/6108816. eCollection 2024.

Abstract

Since contact laser vaporization of the prostate (CVP) was approved by the Japanese insurance system in 2016, the use of a 980 nm diode laser system for CVP has become widespread for treating benign prostate hyperplasia (BPH) patients. Our institute has been implementing CVP for BPH since 2018, treating a total of 93 patients, including 28 with a risk of hemorrhage. This study examines the safety and efficacy of CVP treatment for BPH patients with a hemorrhagic risk. A total of 93 BPH patients with lower urinary tract symptoms (LUTS) underwent CVP between February 2018 and September 2022. All patients were on medications for BPH and were refractory to these medications. The median (mean ± SD) age was 72 (72.9±6.27), and the prostate volume was 64 (68.9±32.5). IPSS, QOL index, and OABSS scores for patients not requiring catheterization were 22 (22.1±6.38), 5 (5.24±0.74), and 6 (7±3.29), respectively. The CVP treatment was performed using a 980 nm diode laser. Of the 93 patients, 28 (30.1%) had a hemorrhage risk. This group included 13 (14.0%) who were continuously receiving anticoagulant and/or antiplatelet agents, 13 (14.0%) who temporarily stopped these medications, and 2 (2.1%) who had a hemorrhage risk due to low platelet counts (< 5.0 × 10/L). Postoperatively, 15 (16.1%) patients, including 11 who were catheterized preoperatively, needed temporary catheterization after CVP treatment. Of these, 14 had their catheters successfully removed. The IPSS score significantly decreased from 22 (22.1±6.38) to 8 (9.02±6.07) ( < 0.0001). In patients with hemorrhagic risk on anticoagulant and/or antiplatelet agents, the change in hemoglobin level before and after surgery was 0.6 g/dL, a difference that was not significant. Two of the 15 patients with hemorrhagic risk experienced hemorrhage 23 and 26 days postoperatively and underwent transurethral coagulation. Other perioperative complications classified as Clavien-Dindo Grade 2 or higher occurred in 4 (4.3%) patients. CVP treatment appears to be acceptable for BPH patients with hemorrhagic risk. In this study, late-onset hemorrhage occurred approximately 1 month postoperatively. Close postoperative follow-up is required.

摘要

自2016年前列腺接触式激光汽化术(CVP)获得日本保险系统批准以来,用于CVP的980纳米二极管激光系统已广泛应用于治疗良性前列腺增生(BPH)患者。自2018年以来,我院一直对BPH患者实施CVP,共治疗93例患者,其中28例有出血风险。本研究探讨CVP治疗有出血风险的BPH患者的安全性和有效性。2018年2月至2022年9月期间,共有93例有下尿路症状(LUTS)的BPH患者接受了CVP治疗。所有患者均在服用治疗BPH的药物,且对这些药物无效。患者的中位(平均±标准差)年龄为72岁(72.9±6.27),前列腺体积为64(68.9±32.5)。无需导尿的患者的国际前列腺症状评分(IPSS)、生活质量指数(QOL)和膀胱过度活动症症状评分(OABSS)分别为22(22.1±6.38)、5(5.24±0.74)和6(7±3.29)。CVP治疗使用980纳米二极管激光进行。在93例患者中,28例(30.1%)有出血风险。该组包括13例(14.0%)正在持续接受抗凝剂和/或抗血小板药物治疗的患者、13例(14.0%)暂时停用这些药物的患者以及2例(2.1%)因血小板计数低(<5.0×10/L)而有出血风险的患者。术后,15例(16.1%)患者(包括11例术前已留置导尿管的患者)在CVP治疗后需要临时留置导尿管。其中,14例患者的导尿管成功拔除。IPSS评分从22(22.1±6.38)显著降至8(9.02±6.07)(<0.0001)。在接受抗凝剂和/或抗血小板药物治疗且有出血风险的患者中,手术前后血红蛋白水平的变化为0.6克/分升,差异不显著。15例有出血风险的患者中有2例在术后23天和26天发生出血,并接受了经尿道凝血治疗。其他围手术期并发症分类为Clavien-Dindo 2级或更高的发生在4例(4.3%)患者中。CVP治疗对于有出血风险的BPH患者似乎是可以接受的。在本研究中,迟发性出血发生在术后约1个月。术后需要密切随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67dc/11671648/3ca3a90c5668/AU2024-6108816.002.jpg

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