Zhao Li, Sha Tianjian, Liu Yufu, Mei Qingsong, Li Haibin, Sun Pinghua, Zhou Haibo, Cai Huaihong
College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
Chem Biomed Imaging. 2024 Sep 20;2(12):817-824. doi: 10.1021/cbmi.4c00052. eCollection 2024 Dec 23.
The large-scale preparation of fluorescent nanomaterials with laboratory-relevant chemical and optical properties will greatly forward their consumer market applications; however, it still remains challenging. In this work, a universal strategy was developed for the rapid and large-scale synthesis of fluorescent sulfur quantum dots that recently has drawn great attention because of their unique optical characteristics. From the fact that empty 3d orbitals of sulfide species are able to bind with lone-pair π electrons of the heteroatomic groups, many amino-group containing compounds, such as amino acid and polyethylenimine molecules, were exploited to synthesize sulfur quantum dots. This 10 min preparation period endowed sulfur quantum dots with bright blue fluorescence and also chirality. Due to the user-friendly and rapid operation, this strategy can be extended to the large-scale synthesis of sulfur quantum dots with a yield of 16.844 g for one batch of experiment. Moreover, it was found that the sulfur quantum dots exhibited a reversible temperature-dependent luminescent property with a sensitivity of 0.72%/°C, which showed excellent intracellular temperature monitoring capability for inflammation-related disease diagnostics.
大规模制备具有与实验室相关的化学和光学性质的荧光纳米材料将极大地推动其在消费市场的应用；然而，这仍然具有挑战性。在这项工作中，开发了一种通用策略，用于快速大规模合成荧光硫量子点，由于其独特的光学特性，这种量子点最近引起了极大关注。基于硫化物物种的空3d轨道能够与杂原子基团的孤对π电子结合这一事实，许多含氨基的化合物，如氨基酸和聚乙烯亚胺分子，被用于合成硫量子点。这10分钟的制备过程赋予了硫量子点明亮的蓝色荧光以及手性。由于操作简便快捷，该策略可扩展到硫量子点的大规模合成，一批实验的产量为16.844 g。此外，发现硫量子点表现出可逆的温度依赖性发光特性，灵敏度为0.72%/°C，这表明其在炎症相关疾病诊断中具有出色的细胞内温度监测能力。
