Rahimi Samin, Shirin Fatemeh, Moassesfar Mahdi, Zafari Hossein, Bahmaie Nazila, Baghebani Kimia, Bidmeshki Yasna, Sajjadi Manesh Seyede Masoumeh, Rasoulzadeh Darabad Kasra, Bahmaie Massoud, Nouri Elham, Kilic Ahmet, Ansarin Melika, Özışık Pınar, Simsek Ender, Ozensoy Guler Ozen
Department of Genetics, Faculty of Natural Sciences, Tabriz University, 5166616471 Tabriz, Iran.
Department of Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, 1651153311 Tehran, Iran.
Front Biosci (Landmark Ed). 2024 Dec 20;29(12):422. doi: 10.31083/j.fbl2912422.
As one of the most common solid pediatric cancers, Neuroblastoma (NBL) accounts for 15% of all of the cancer-related mortalities in infants with increasing incidence all around the world. Despite current therapeutic approaches for NBL (radiotherapies, surgeries, and chemotherapies), these approaches could not be beneficial for all of patients with NBL due to their low effectiveness, and some severe side effects. These challenges lead basic medical scientists and clinical specialists toward an optimal medical interventions for clinical management of NBL. Regardingly, taking molecular and cellular immunopathophysiology involved in the hypoxic microenvironment of NBL into account, it can practically be a contributing approach in the development of "molecular medicine" for treatment of NBL. Interestingly, pivotal roles of "herbal medicine" in the hypoxic microenvironment of NBL have been extensively interrogated for treating a NBL, functionally being served as an anti-cancer agent via inducing a wide range of molecular and cellular signaling, like apoptosis, cell cycle arrest, and inhibiting angiogenesis. Hence, in this review study, the authors aim to summarize the anti-tumor effects of some medicinal plants and their phytoconstituents through molecular immunopathophysiological mechanisms involved in the hypoxic microenvironment of NBL. In addition, they try to open promising windows to immune gene-based therapies for NBL "precision medicine" through clinical advantages of herbal and molecular medicine. An interdisciplinary collaboration among translation and molecular medicine specialists, immunobiologists, herbal medicine specialists, and pediatric neuro-oncologists is highly recommended.
作为最常见的小儿实体癌之一，神经母细胞瘤（NBL）占婴儿所有癌症相关死亡人数的15%，且在全球范围内发病率不断上升。尽管目前针对NBL有多种治疗方法（放疗、手术和化疗），但由于其疗效低且有一些严重副作用，这些方法并非对所有NBL患者都有益。这些挑战促使基础医学科学家和临床专家寻求针对NBL临床管理的最佳医学干预措施。考虑到NBL缺氧微环境中涉及的分子和细胞免疫病理生理学，它实际上可以成为开发治疗NBL的“分子医学”的一种有效方法。有趣的是，“草药医学”在NBL缺氧微环境中治疗NBL的关键作用已被广泛研究，它通过诱导多种分子和细胞信号传导，如凋亡、细胞周期阻滞和抑制血管生成，在功能上作为一种抗癌剂。因此，在本综述研究中，作者旨在通过NBL缺氧微环境中涉及的分子免疫病理生理机制，总结一些药用植物及其植物成分的抗肿瘤作用。此外，他们试图通过草药医学和分子医学的临床优势，为基于免疫基因的NBL“精准医学”疗法打开有前景的窗口。强烈建议翻译和分子医学专家、免疫生物学家、草药医学专家和儿科神经肿瘤学家之间进行跨学科合作。
