脑室内注入腐胺对大鼠下丘脑和尾状核中腺苷甲硫氨酸脱羧酶的影响。

Effect of intraventricular putrescine on adenosylmethionine decarboxylase in rat hypothalamus and caudate nucleus.

作者信息

Ientile R, Ruggeri P, Russo P, Macaione S

出版信息

J Neurochem. 1985 Apr;44(4):1315-7. doi: 10.1111/j.1471-4159.1985.tb08760.x.

DOI:10.1111/j.1471-4159.1985.tb08760.x

Abstract

Effects of intracerebroventricularly injected putrescine on adenosylmethionine decarboxylase activity in rat hypothalamus and caudate nucleus were studied. Doses that lacked the capacity to produce behavioral and electrocortical epileptogenic disorder caused a significant activation of enzyme occurring between 10 and 15 min after injection. The changes in hypothalamic and caudate nucleus enzyme activity after putrescine administration were dose-dependent, and they supported the assumption that limiting putrescine concentration in vivo may play a role in adenosylmethionine decarboxylase regulation.

摘要

研究了脑室内注射腐胺对大鼠下丘脑和尾状核中腺苷甲硫氨酸脱羧酶活性的影响。缺乏产生行为和皮层脑电图癫痫源性障碍能力的剂量，在注射后10至15分钟之间引起了酶的显著激活。腐胺给药后下丘脑和尾状核酶活性的变化呈剂量依赖性，它们支持这样一种假设，即体内限制腐胺浓度可能在腺苷甲硫氨酸脱羧酶调节中起作用。